Other

Stewart Italia Srl

Calignano, Antonio

Cuomo, Rosario

Boatto, Gianpiero

Rimoli, Maria Grazia

Maria Nieddu

Antonio Calignano

Giovanna La Rana

Maria Grazia Rimoli

Rosario Cuomo

Gianpiero Boatto

Enrico Abignente

Daniela Melisi

Annalisa Curcio

Elvira Luongo

Oscar Sasso

Giovanni Sarnelli

Roberto Russo

Carla Cirillo

Salvatore De Lucia

Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.

Galactosylated pro-drugs of non-steroidal anti-inflammatories with improved pharmacokinetic characteristics and reduced toxicity of the starting drug

Growing community of inventors

Sassari, Italy

Maria Nieddu