The United States of America, As Represented by the Secretary, Department of Health and Human Services

Margaret C Bash

Che-Hung Robert Lee

Gregory Price

Kathryn Matthias

Immunogenic compositions are disclosed that includemicrovesicles, such as outer membrane vesicles (OMV) and/or blebs, from PorAPorB, such as PorAPorBRmpM. These immunogenic compositions are of use to induce an immune response to, includingand

immunogenic compositions

Immunogenic compositions that include a bacterial capsular polysaccharide conjugated to a carrier protein are described. In some embodiments, the bacterial capsular polysaccharide is acapsular polysaccharide. The carrier protein includes anfactor H binding protein (fHbp) linked to cholera toxin subunit B (CTB). Administration of the immunogenic compositions elicits an immune response that includes production of meningococcal polysaccharide-specific and fHbp-specific antibodies. Use of the immunogenic compositions as meningococcal vaccines is also described.

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Silver Spring, MD, United States of America

Margaret C Bash