Mayo Foundation for Medical Education and Research

Malayannan Subramaniam

Thomas C Spelsberg

Nalini M Rajamannan

Patrick C Roche

Merry Jo Velasquez

Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.

Transgenic TIEG non-human animals

Methods to determine TIEF-1 polypeptide, or genetic rearrangements in the TIEF-1 gene, in a sample are provided. Also provided are TIEF-1 specific antibodies and nucleic acid probes, and methods of employing those antibodies and probes to detect breast cancer in situ in a mammalian tissue sample.

TGF-&bgr; inducible early factor-1 (TIEF-1) and a method to detect breast cancer

An isolated and purified DNA molecule encoding TGF-.beta. inducible early factor-1 (TIEF-1) is provided. A method of isolating a growth factor- or differentiation factor-inducible gene is also provided.

Growing community of inventors

Zumbrota, MN, United States of America

Malayannan Subramaniam