Bristol-myers Squibb Compnay

Other

Luciano Mueller

William Joseph Metzler

Keith Lewis Constantine

Brian Lee Claus

Malcolm Evan Davis

Peter W Glunz

Eldon Scott Priestley

Paul E Morin

Xiaojun Zhang

Nicholas Ronald Wurtz

Michael J Smith

Vladimir Ladziata

Daniel L Cheney

Brandon Lee Parkhurst

Harold J Malone

Haiying Tang

Deuterated polymer-biomolecule conjugates and the synthesis and use of deuterated polymer-biomolecule conjugates for detecting the location of specific molecules, e.g., cell surface molecules, in a subject, and for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

Methods and compositions for deuterated biologics

A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method.

Protein-ligand NOE matching for high-throughput structure determination

The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, C, D, L, M, W, Z, Z, Z, Z, R, R, R, R, R, R, R, R, R, and Rare as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.

Macrocyclic factor VIIa inhibitors useful as anticoagulants

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Princeton, NJ, United States of America

Luciano Mueller