Fondazione Cariplo

Fondazione Is. Insubrico Di Ricerca Per La Vita

Fondazione Istituto Insubrico Di Ricerca Per La Vita

Lucia Carrano

Marino Nebuloni

Giacomo Carenzi

Gianpaolo Candiani

Alberto Milanese

Linda Cavaletti

Monica Abbondi

Mara Brunati

Anna Taravella

Alessandro Sigurta'

Paola Turconi

Giacomo Enrico Carenzi

The invention relates to a new family of proteolytic enxymes having the ability to hydrolize at a pH between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by anstrain. The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of nativestrains, mutants thereof, or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention. The enzyme compositions comprising at least one endopeptidase of the invention are useful for the treatment and/or prevention of celiac sprue, dermatitis herpetiformis and any other disorder associated with gluten intolerance as ingredients of pharmaceutical formulations or as additives of foods and drinks.

[object Object]

A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorption with respect to crystalline tomoxiprole and is particularly suitable for the production of pharmaceutical oral dosage forms, such as tablets and capsules, where rapid onset of therapeutical action is required. A method of manufacture of the complex is also described and claimed.

Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof

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Legnano, Italy

Lucia Carrano