Spa Societa Prodotti Antibiotici S.p.a.

Other

Prospa N.v.

Lorenzo Ferrari

Tiberio Bruzzese

Ernani Dell'Acqua

Eric Arthur Johnson

Giorgio Quaglia

Aurelio F Notarianni

Process for the decontamination of vegetable foods from Listeria-sp. which consists in adding solutions of lysozyme, non-toxic and physiologically compatible salts thereof, to said foods, with or without adjuvant substances, at concentrations suitable for affording decontamination.

Process for bacterial decontamination of vegetable foods

A new benzothiazine derivative, that is N-(2-pyridyl)-2-methyl-4-cinnamoyloxy-2H-1,2-benzothiazine-3-carboxamido 1,1-dioxide has been prepared. Owing to its peculiar ester structure, obtained by condensation with cinnamic acid, the new product is endowed with so outstanding pharmacological and toxicological activities, particularly with reference to its tolerableness, to make it a therapeutically valuable anti-inflammatory drug.

Anti-inflammatory 1,2-benzothiazines

The present invention provides compounds of the general formula: ##STR1## wherein Y is a hydrogen atom or an acetyl radical, R is a hydrogen atom, a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 5 carbon atoms, which can be substituted by hydroxyl or amino groups, a phenyl radical which can be substituted by hydroxyl, amino or carboxyl groups or by alkoxycarbonyl radicals, an arylalkyl radical or a cycloalkyl radical containing 3 to 6 carbon atoms and R' is a hydrogen atom, a straight-chained or branched saturated or unsaturated aliphatic hydrocarbon radical containing up to 8 carbon atoms, which can be substituted by hydroxyl or amino groups, a cycloalkyl radical containing 3 to 6 carbon atoms or an arylalkyl radical; and the pharmacologically acceptable salts thereof. The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them.

Derivatives of rifamycins, their preparation and pharmaceutical

The present invention provides a method of treating inflammatory and pyretic conditions in mammals, including humans, which comprises administering a derivative of 1,2:5,6-di-O-isopropylidene-.alpha.-D-glucofuranose to a mammal requiring treatment for an inflammatory or pyretic condition.

Glucofuranose derivatives

The present invention is concerned with a method for the treatment of benign prostatic hypertrophy in male humans, comprising administering an effective amount of a compound selected from the group consisting of partricin, C.sub.1 -C.sub.6 alkyl ester of partricin and C.sub.1 -C.sub.6 alkyl ester of N-mono- and N,N-disubstituted partricin, the N-substituents being C.sub.1 -C.sub.6 alkyl or carboxylic acyl, to a human male suffering from benign prostatic hypertrophy.

Method for the treatment of benign prostatic hypertrophy

The present invention provides a method of treating domestic animals which are infected or endangered by micro-organisms, as well as solid and liquid nutriments for domestic animals comprising lysozyme and/or at least one non-toxic salt thereof. The present invention also provides, as new compounds, lysozyme phosphate, glycerophosphate, lactate, gluconate and hexametaphosphate, as well as a process for the preparation thereof.

Method of treating domestic animals

The present invention is concerned with a method for the treatment of dyslipidaemia and arteriosclerosis in human beings, comprising administering an effective amount of an active compound selected from the group consisting of partricin, alkyl esters of partricin and alkyl esters of N-mono- or disubstituted partricin to a human being in need of said treatment. If desired, the active compound can be administered in the form of a water-soluble complex with a compound selected from the group consisting of benzalkonium chloride, sodium lauryl sulphate, sodium tetradecyl sulphate, sodium desoxycholate and sodium dehydrocholate.

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Milan, Italy

Lorenzo Ferrari