William Marsh Rice University

Georgia Tech Research Corporation

E. R. Squibb Sons, Inc.

Luna Innovations Inc.

Lon J Wilson

Uri Sagman

Yuri Mackeyev

Jaehong Kim

Michael F Tweedle

Michael G Rosenblum

Kyle Ryan Kissell

John Michael Alford

Pedro J J Alvarez

John T Wharton

Jaesang Lee

Keith Bennett Hartman

Daniel W Lee

Joseph E Bradshaw

Compositions and methods related to carbon nanotubes are provided. More particularly, imaging agents comprising carbon nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon nanotube loaded with contrast agent; introducing the imaging agent into a cell; and imaging the cell to detect the presence of the imaging agent.

Carbon nanotube based imaging agents

In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible light. In some embodiments, the fullerene derivatives are aminofullerenes containing a plurality of amine-terminated moieties covalently bonded to the fullerene cage. The fullerene derivatives may optionally be covalently bonded to a substrate surface for use in photocatalytic disinfection systems for removing various contaminants including, for example, bacteria, viruses, protozoa and chemical pollutants. Methods using the present fullerene and aminofullerene derivatives in various purification processes are also described herein.

Fullerene compositions and methods for photochemical purification

A method of removing metal impurities from carbon nanotubes includes treating carbon nanotubes with distilled bromine in a substantially oxygen- and water-free atmosphere and then removing the distilled bromine from the carbon nanotubes. Purified carbon nanotubes having an iron content from about 2.5 to about 3.5 by weight that are substantially free of derivatization at the ends and defect sites are made available via this method.

Facile purification of carbon nanotubes with liquid bromine at room temperature

Herein we disclose a composition, comprising a C-Ab, wherein Cis a fullerene or nanotube comprising n carbon atoms, and Ab is a moiety comprising an antigen-binding site and is linked to the Cn. The composition can further comprise a therapeutic molecule associated with the C-Ab. Also, we disclose a method of treating a disease in a mammal, comprising administering to the mammal an effective amount of the composition.

Fullerenes in targeted therapies

An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.

Fullerene (C60)-based X-ray contrast agent for diagnostic imaging

A non-toxic contrast agent for enhancing contrast in in vivo magnetic resonance measurements, comprised of a water-soluble, stable paramagnetic fullerene that is free of paramagnetic metal species. A preferred contrast agent is a fullerol having at least one unpaired electron.

Fullerene contrast agent for magnetic resonance imaging and spectroscopy

Porphyrin-complex compounds useful as contrast agents in magnetic resonance imaging (MRI) having the formula ##STR1## where Y is a transition metal such as Fe.sup.III, Cr.sup.III, Mn.sup.III, Mn.sup.II and Cu.sup.II, X is a biologically well-tolerated metal complexing anion such as Cl.sup.-, CF.sub.3 SO.sub.3 or CF.sub.3 COO.sup.- and R is a nonionic water solubilizing moiety.

Growing community of inventors

Houston, TX, United States of America

Lon J Wilson