Council of Scientific and Industrial Research

Piramal Life Sciences Limited

Piramal Enterprises Limited

Lisette D'Souza

Chandrakant Govind Naik

Prabha Devi

Ram Asrey Vishwakarma

Girish Badrinath Mahajan

Meenakshi Sivakumar

Becky Mary Thomas

Satish Namdeo Sawant

Koteppa Pari

Saji George

Asha Peketi

Ely Rodrigues

Solimabi Wahidulla

Zarine Eruch Patel

Sridevi Krishna

Rajan Mukund Panshikar

Sreekumar Sankaranarayanan Eyyammadichiyil

Prabhu Dutt Satyanarayan Mishra

Prafull Vasant Ranadive

This invention relates to a novel purified compound PM181104, of formula: of molecular weight 1514 and molecular formula CHNOS; which is obtained by fermentation of the microorganism belonging tospecies (ZMA B-1/MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging tospecies (ZMA B-1/MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.

Antibacterial compounds

The present invention relates to a plant mangrove-associated fungus, and a simple and efficient method of obtaining high yield of pure mannitol from a plant mangrove-associated fungus, said method comprising steps of cutting the leaves into small pieces and placing it on potato dextrose agar (PDA) plates for 48 hours, maintaining the culture at temperature ranging between 26-47&#xb0; C. and salinity ranging between 4-32 ppt with occasional stress conditions for about 17-19 days to obtain mycelial mat, sonicating the mat to lyse the cells, extracting crude from the sonicated mat using methanol repeatedly, concentrating the crude, treating the concentrated crude extract with solvents of increasing polarity, obtaining aqueous fraction as white powder residue after the treatment containing crude mannitol, purifying the crude mannitol by chromatography to obtain pure mannitol with about 75% of the total crude extract.

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Growing community of inventors

Dona Paula, India

Lisette D'Souza