Institut National De La Sante Et De La Recherche Medicale

Sanford-burnham Medical Research Institute

UniversitÉde Strasbourg

Inserm

Lise Roth

Erkki I Ruoslahti

Tambet Teesalu

Kazuki Sugahara

Dominique Aunis

Cécile Nasarre

Pierre Hubert

Sylvie Dirrig-Grosch

Dominique Bagnard

Gerard Cremel

Gérard Cremel

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides

The present invention concern a peptidic antagonist of class III semaphorins/neuropilins complexes comprising an amino acid sequence, which is derived from the transmembrane domain of a protein selected in the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin Beta 1 and integrin beta 2, and including at least a GxxxG motif, eventually fused to an heterologous sequence; a nucleic acid encoding for said peptidic antagonist, a pharmaceutical composition comprising such a peptidic antagonist or a nucleic acid encoding thereof and uses thereof.

Peptidic antagonists of class III semaphorins/neuropilins complexes

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Strasbourg, France

Lise Roth