Sunshine Guojian Pharmaceutical (shanghai) Co., Ltd.

Liangfeng Jiang

Jie Zhao

Haomin Huang

Zhenping Zhu

Lei Huang

Yuping Huang

Huiling Wu

Disclosed are antibodies binding to human IL-4R, having identical variable regions and different constant regions, wherein the variable regions can specifically bind to human IL-4R, and the constant regions affect the activity of the whole antibody through an amino acid site mutation. The above-mentioned antibodies can be used to treat diseases related to IL-4R overexpression, such as atopic dermatitis, asthma, etc., and thus possesses good clinical application prospects.

Antibodies binding to human IL-4R, preparation method therefor and use thereof

Disclosed is a monoclonal antibody that binds to human IL-5. The monoclonal antibody that binds to human IL-5 has a good biological activity for inhibiting TF-1 cell proliferation induced by IL-5 and blocking the interaction between IL-5 and IL-5RA, has a different antigen epitope from the known anti-human IL-5 antibody, can be used for preparing drugs for treating diseases mediated by the over-expression of eosinophilic granulocytes (such as asthma), and has a good clinical application prospect.

Monoclonal antibody binding to human IL-5, preparation method therefor and use thereof

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Shanghai, China

Liangfeng Jiang