Huawei Technologies Co., Limited

Shanghaitech University

International Business Machines Corporation

Graphic Packaging International, Inc.

Honeywell International Inc.

Chinese Academy of Sciences

Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Zte Corporation

Alcatel Lucent

Covestro Deutschland Ag

Shoei Chemical Inc.

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Sabic Global Technologies B.v.

Advanced New Technologies Co., Ltd.

Li Yang

Hongzhuo Zhang

Tianle Deng

Xiaoying Xu

Xiaoxiao Zheng

Jia Chen

Xingxu Huang

Xiao Ling Chen

Lingli Pang

Lei Zhang

Colin P Ford

Raymond Rudolph Spivey, Sr

Jean-Manuel Gomes

Weikang Tao

Lianshan Zhang

Kaijie Zhou

Guoqing Cao

Rui Liu

Xiangdong Qu

Jijun Yuan

Wen Peng

Chen Zhang

Yu Chen Zhou

James Armand Baldwin

Haiyan Luo

Xiang Li

Xiaoli Shi

Jing Chen

Binsong Tang

Xin Ye

Jianmin Fang

James C Fogle

He Huang

Wenruo Zhu

Yang He

Xudong Yang

Xiaoqian Jia

Jianping Zuo

Yingzhe Li

Wei Feng

ShaoHua Fang

Ying Wang

Zhe Chen

Bei Yang

James Yeh

Dong Luo

Lijie Wang

Jufang Lin

Youhong Hu

Xiao Wang

Dong Lu

Xiaojuan Shi

Yuzhen Xu

Hedley C Davis

Xiao Yu Wang

Yajing Liu

Sean Gao

Da Lei Zhang

Peter Ian Macdonald

Limin Zeng

Feifei Liu

Xiankun Tong

Gladys Wong

Cai Yigang

Yunzhe Zhang

Wuhong Chen

Xiaosa Li

Lingling Chen

Chuxiao Liu

Fang Nan

Jianan Li

Du Chenyang

Chen Guo

Han Long

Lan Ying Shen

Jie Zou

Hongbing He

Ling Su

Zhang Liu

Hengjie Lai

Pei Ke

Lily Ren

Huiqin Chen

Wenli Mei

Haofu Dai

Yanmei Wei

Wenhua Dong

The present invention provides use of a circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length and/or a promoting agent of the circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length in preparation of a medicament for treating systemic lupus erythematosus.

Application of circular RNA in preparing drug for treating systemic lupus erythematosus

A flow conditioner includes a group of flow conditioning units including a first flow conditioning unit and a second flow conditioning unit. The flow conditioner also includes a mixing space for developing a flow. The mixing space is located between the first and second flow conditioning units. One of the first or second flow conditioning units can include one or more of a shaper or a reducer, and the other of the first or second flow conditioning units can include one or more shapers.

Flow conditioner for severe flow disturbances

A rectifier and a flowmeter, the rectifier including a fairing, wherein a first rectifying section () positioned at the upstream, a reducing section () positioned at the midstream and a second rectifying section () positioned at the downstream, can be arranged in the fairing. The first rectifying section and the second rectifying section are respectively provided with a group of rectifying channels parallel to the flow direction of fluid, and a through-hole () can be formed in the reducing section. The rectifier can provide improved rectification effects.

Rectifier and flowmeter

Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.

Fusion proteins for improved precision in base editing

The present application provides a network information reporting method and apparatus, a user equipment, a service node, and a medium. The network information reporting method includes: detecting, in a case where a user equipment is operating in a first-type network, a cell of a second-type network; and reporting cell network information to a service node of the first-type network, the cell network information including network information corresponding to a detected target cell of the second-type network.

Network information reporting method and apparatus, user equipment, service node and medium

Provided are fusion proteins that include an apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A) and a clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) protein, optionally further with uracil glycosylase inhibitor (UGI). Such a fusion protein is able to conduct base editing in DNA by deaminating cytosine to uracil, even when the cytosine is in a GpC context or is methylated.

Fusion proteins for base editing

Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion protein may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitor, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

Inhibition of unintended mutations in gene editing

Embodiments of the present disclosure provide a data transmission method, terminal, and base station, relate to the communications field, and can improve data packet transmission efficiency. The data transmission method includes: receiving, by a terminal in an idle state, a first resource sent from a base station, where the first resource is used by the terminal to send an uplink application layer data packet to the base station; and sending, by the terminal, on the first resource, the uplink application layer data packet to the base station. The data transmission method is applied to the data transmission system.

Data transmission method, terminal, and base station

The present invention relates to a polycarbonate composite having an increased pencil hardness, comprising a polycarbonate substrate prepared from a thermoplastic aromatic (co)polycarbonate having a glass-transition temperature in the range of 160 to 210&#xb0; C.; and a coating on said substrate, said coating being formed by curing a polysiloxane-based thermosetting coating material at a temperature in the range of 140 to 210&#xb0; C. for 0.5 to 2 hours. The polycarbonate composite has a pencil hardness higher than H, as measured according to ASTM D3363. The present invention also relates to a method for producing said polycarbonate composite and an article comprising the same.

Polycarbonate composite having an increased pencil hardness

Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion proteins may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitory domain, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders.

PD-1 antibody, antigen-binding fragment thereof, and medical application thereof

This application provides a data transmission method and apparatus. The method includes: receiving, by a first network node, first indication information sent by a second network node, where the first indication information is used by the first network node to determine first duration, and the first duration is duration from receiving a first data packet by the first network node to sending the first data packet by the first network node; and sending, by the first network node, the first data packet based on the first indication information. The data transmission method and apparatus provided in embodiments of this application help ensure that a communications network transmits a data packet based on a duration requirement.

Data transmission method and apparatus

A method includes: receiving, by a first access device, a random access message sent by user equipment; and sending, by the first access device, first system information to the user equipment based on the random access message, where the first system information includes cell reselection information related to the first access device. According to the present invention, cell reselection information can be transferred in a random access procedure.

System message transmission method, related device, and communications system

Embodiments of the present disclosure provide a method for accessing a network by a user equipment (UE), and an access device. The method includes: sending, by a source side access device, an access indication message to a UE, where the access indication message is used to instruct the UE to access a target side access device; or sending, by a source side access device, a first notification message to a target side access device, where the first notification message is used to instruct the target side access device to send, to a UE, access information used to instruct the UE to access the target side access device; and in a process in which the UE accesses the target side access device, maintains a connection between the UE and the source side access device.

Method for accessing network by user equipment, and access device

Embodiments of the present disclosure provide a paging method, a device, and a system, and relate to the communications field, so as to reduce signaling exchange performed when an access network device pages UE, save a network resource, and improve data transmission efficiency. The paging method includes: receiving, by user equipment (UE), paging information sent by an access network device, where the paging information is used to instruct the UE to send a paging response by using an uplink data sending resource; and obtaining, by the UE, the uplink data sending resource according to the paging information, and sending paging response information to the access network device by using the uplink data sending resource.

Paging method, device, and system

Growing community of inventors

Shanghai, China

Li Yang