The Scripps Research Institute

Leslie Krushel

Gerald M Edelman

Wei Zhou

Vincent P Mauro

Stephen A Chappell

Geoffrey Owens

Kathryn L Crossin

Olaf Sporns

Jason K Pinkstaff

Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, compositions that include such translational regulatory elements are provided, as are methods of using the translational regulatory elements.

Synthetic internal ribosome entry sites and methods of identifying same

Methods and compositions are disclosed that are useful for the inhibition of glial cell proliferation by means of binding inhibiting agents to neural cell adhesion (N-CAM) molecules present on the cell surface. Such inhibiting agents can be peptides derived from the homophilic binding region of N-CAM, monoclonal antibodies, polyclonal antibodies, Fab' fragments, and the like. Exemplary N-CAM homophilic peptides are 7 to 90 amino acid residues having a positively charged amino acid residue separated from a negatively charged amino acid residue by five intervening amino acid residues.

Inhibition of glial cell proliferation with N-CAM homophilic peptides

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Denver, CO, United States of America

Leslie Krushel