Richter Gedeon Vegyeszeti Gyar Rt

Kozponti Valto-es Hitelbank Rt. Innovacioalap

Lajos Wolf

Endre Csanyi

Jozsef Borsi

Erzsebet Mago Nee Karacsony

Katalin Pik

Lehel Koch

Emil Minker

Kalman Szendrei

Zsuzsanna Rozsa

A polysaccharide-concentrate obtained from plant of the genera Cucurbitaceae, Papilionaceae, Tiliaceae, Labiate, Malvaceae, Asteraceae, Umbelliferae, Rutaceae, Chenopodiaceae, Linaceae, Rosaceae and Plantaginaceae by extraction with water and precipitation of the polysaccharide with alcohol or acetone, if desired after further purification. The polysaccharides having a molecular weight between 75,000-2,000,000, containing maximum 5% of nitrogen, maximum 5% of phosphorus (expressed in P.sub.2 O.sub.5), maximum 25% of ash, minimum 30% of reducing sugar, minimum 60% of total sugar (after acidic hydrolysis, expressed as glucose) has been shown to have especially anti-inflammatory activity.

Biologically active polysaccharide concentrates and process for

New compounds of the formula ##STR1## wherein R is hydrogen or methyl group,

Compounds with ergoline skeleton

New compounds of the general formula (I) ##STR1## wherein R stands for hydrogen or methyl group, x y stands for a group of the formula ##STR2## and R.sub.1 stands for a group of the formula (III), (IV) or (V) ##STR3## wherein n is an integer from 4 to 10, ARE PREPARED BY ACYLATING A COMPOUND OF THE GENERAL FORMULA (II), ##STR4## wherein R and x y each have the same meanings as defined above, and R.sub.2 stands for a group of the formula (VI), (VII) or (VIII), ##STR5## with a C.sub.6-12 carboxylic acid or a C.sub.6-12 carboxylic acid halide. The new compounds of the general formula (I) and their acid addition salts can be used as antidepressants and antiserotonine agents with prolonged effects.

Growing community of inventors

Budapest, Hungary

Lajos Wolf