Manus Bio Inc.

Krishna Patel

Ajikumar Parayil Kumaran

Jason Eric Donald

Ryan Philippe

Liwei Li

Ryan Lim

Swati Gupta

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products inleaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Uridine diphosphate-dependent glycosyltransferase circular permutants

The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.

Microbial production of steviol glycosides

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Cambridge, MA, United States of America

Krishna Patel