Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Nippon Beet Sugar Mfg., Co., Ltd.

Kozo Asano

Fusao Tomita

Hirofumi Nakano

Makoto Morimoto

Isao Kawamoto

Isami Takahashi

Hiroshi Kase

Kunikatsu Shirahata

Tadashi Ashizawa

Yuzuru Matsuda

Takao Iida

Keiichi Takahashi

Koji Yamada

Tatsuya Tamaoki

Katsuichi Shuto

Toru Yasuzawa

Tsutomu Aritsuka

Mitsunobu Hara

Hiroto Kikuchi

Noriaki Hirayama

Kazuhisa Fujimoto

Tohru Yasuzawa

Norimitsu Takagi

Hisayo Nomoto

Hiroaki Sakurai

Yoshihiro Senba

Kazuyuki Iwahashi

In the invention, highly pure crystals of difructose dianhydride III (di-D-fructofuranose-1,2':2,3&#x2032;-dianhydride; hereinafter referred to as DFA III) are produced by adding 5% or less of powdered active carbon to a DFA III containing purified solution containing DFA III of 90% or more purity at a concentration of R-Bx 10-60, preferably 40-55, and after stirring, applying the mixture to solid-liquid separation (filtration with diatomaceous, filtration through a membrane filter, ultrafiltration, or continuous centrifugal separation) and concentrating the separated liquid part, followed by immediate crystallization. In the process of the invention, DFA III crystals can be produced efficiently and industrially, and the resulting crystals can be used for various purposes in pharmaceuticals or food and drink since they have no smell. This is characteristics of the invention different from the prior art products.

Process for purifying difructose dianhydride III

A novel compound, DC-107, is produced by culturing a microorganism belonging to the genus Streptomyces. It is useful as a medicine because of its antibacterial and anti-tumor activity.

Compound DC-107 produced by Streptomyces sp.

UCN-01 having an anti-tumor activity and an anti-bacterial activity is produced by culturing a microorganism belonging to the genus Streptomyces.

UCN-01 and process for production thereof

Antibiotic compounds DC-92B and DC-92D

A new substance K-259-2 having a molecular formula of C.sub.21 H.sub.18 O.sub.7, a molecular weight of 382 and an elemental analysis (%) of H: 4.50, C: 65.53 and N: 0. This substance is of interest in providing a new vasodilating agent in view of its ability to dilate the blood vessel, particularly the artery, of mammals. This substance may be obtained by fermentation of a microorganism Micromonospora sp. K-259 (FERM BP 569).

Substance K-259-2 and a process for producing the same

Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities. Some of these compounds are produced by incubation of a microorganism.

Phenazine carboxylic acid derivatives and a process for production

A novel physiologically active substance K-252 having an antiallergic action is produced by culturing a microorganism of the genus Nocardiopsis.

Physiologically active substance K-252, process for producing same and

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Machida, Japan

Kozo Asano