Bristol-myers Squibb Compnay

Nereus Pharmaceuticals, Inc.

Bristol-myers Company

Bristol Meyers Squibb Company

Celgene International Ii Sarl

Triphase Research and Development I Corp.

Kin S Lam

Daniel R Schroeder

James A Matson

Jacqueline M Mattei

Grace A Hesler

Ginger Tsueng

Koji Tomita

Wenying Li

Salvatore Forenza

Barbara Christine Potts

Benjamin Nicholson

Scott Sherman Mitchell

Donald R Gustavson

John E Leet

Sandra J Hofstead

Ronald L Berry

Katherine Anne Reed

Jacqueline M Veitch

Ta-Hsiang Chao

Venkata Rami Reddy Macherla

Jennifer Grodberg

Grace A McClure

Xiaohua Huang

Ram Rao Manam

Saskia Neuteboom

Cheryl L Billstrom

Thomas T Dabrah

Donald J White

Leonard A McDonald

Venkat Macherla

Daniel M Brown

Murray A Kaplan

Jie Chen

Michael A Palladino

James A Bush

Brian A Dougherty

Katherine A McArthur

Zizhuo Xing

Yue-Zhong Shu

Yijun Chen

Christopher L Steele

Helen A Ax

Judith A Veitch

Kimberly Brown

Laura Turner

Scott S Mitchell

Barbara C Potts

Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin Bat specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.

Salt formulations for the fermentation of marine microorganisms

Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.

Anti-cancer and anti-microbial oxazolidinones

Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.

Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs

Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

[3.2.0] Heterocyclic compounds and methods of using the same

Anti-cancer and anti-microbial 5-membered heterocyclic compounds

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

Bis-indole pyrroles useful as antimicrobials agents

Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.

Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds

A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.

Microbial transformation method for the preparation of an epothilone

Fermentation of Nocardia sp. ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic activity against Gram-positive bacteria and has in vivo efficacy in animals.

Halo- or hydroxy-substituted nocathiacin antibiotics

Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.

Nocathiacin antibiotics

Growing community of inventors

Cheshire, CT, United States of America

Kin S Lam