Exelixis, Inc.

Kevin Patrick Keegan

Thomas J Stout

David J Matthews

Alison Joly

Michael Martin Ollmann

Lori Friedman

Jeffrey Scott Larson

Darren Platt

Andrew Roy Buchman

Casey Kopczynski

Stephanie A Robertson

Lynn Marie Young

Michael Martin Ollman

Madelyn Robin Demsky

A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53 protein. They can also be used in methods for studying p53 activity and identifying other genes that modulate the function of, or interact with, the p53 gene. Nucleic acid and protein sequences for Drosophila p33 and Rb tumor suppressors are also described.

Insect p53 tumor suppressor genes and proteins

Human Ect2 polypeptide, fragments and derivatives, along with vectors and host cells for expression and production of Ect2 polypeptide are provided. Various methods of screening for agents that modulate interaction of Ect2 with an Ect2 binding agent, including high throughput methods, are also provided.

Methods of screening for agents that modulate the interaction of human ECT2 polypeptide with an ECT2 binding target

Novel nucleic acids that are homologs of genes implicated in cancer are described that have been isolated from These novel nucleic acids can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in novel gene expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with gene products implicated in cancer. They can also be used in methods for studying gene activity and identifying other genes that modulate the function of, or interact with, genes implicated in cancer.

Drosophila homologues of genes and proteins implicated in cancer and methods of use

Human ECT2 polypeptide

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San Diego, CA, United States of America

Kevin Patrick Keegan