Battelle Memorial Institute

Frito-lay North America, Inc.

Kevin Minard

Rick Wendell Bajema

Jason Ballengee

Jian Zhi Hu

Robert A Wind

Richard E Jacob

Brett Amidan

Donald N Rommereim

Paul D Majors

A non-invasive NMR based apparatus for measuring a food attribute (moisture, sugar content) in food products comprises a magnetic chamber, an RF pulsing device attached to the magnetic chamber, a sensor receiver, and a data processing unit in communication with the sensor receiver. The pulsing device exposes the food ingredients/snacks to an RF field and produces an NMR response signal that is detected by the sensor receiver. The data processing unit quantitatively measures a food attribute of the food product based on the NMR response signal.

NMR-based non-invasive and quantitative food attribute measurement apparatus and method

NMR based non-invasive and quantitative food attribute measurement apparatus and method

A method and apparatus for detecting the presence of abnormal tissues of the present invention utilizing a magnetic resonance imaging system in communication with a computer. The apparatus is configured to define a confidence region using a probability based confidence interval calculation such as multivariate or bivariate analysis for at least two parameters in a normal tissue sample by making a magnetic resonance image, and then to evaluate a second sample by making a magnetic resonance image. Parameters detectable by magnetic resonance imagingare selected from t, t, t, signal intensity, and diffusion.

Method and apparatus for enhanced in vivo MRI imaging

Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about 54&#xb0;44' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.

Methods for magnetic resonance analysis using magic angle technique

The present invention relates to a probe and processes useful for magnetic resonance imaging and spectroscopy instruments. More particularly, the invention relates to a MR probe and processes for obtaining resolution enhancements of fluid objects, including live specimens, using an ultra-slow (magic angle) spinning (MAS) of the specimen combined with a modified phase-corrected magic angle turning (PHORMAT) pulse sequence. Proton NMR spectra were measured of the torso and the top part of the belly of a female BALBc mouse in a 2T field, while spinning the animal at a speed of 1.5 Hz. Results show that even in this relatively low field with PHORMAT, an isotropic spectrum is obtained with line widths that are a factor 4.6 smaller than those obtained in a stationary mouse. Resolution ofH NMR metabolite spectra are thus significantly enhanced. Results indicate that PHORMAT has the potential to significantly increase the utility ofH NMR spectroscopy for in vivo biochemical, biomedical and/or medical applications involving large-sized biological objects such as mice, rats and even humans within a hospital setting. For small-sized objects, including biological objects, such as excised tissues, organs, live bacterial cells, and biofilms, use of PASS at a spinning rate of 30 Hz and above is preferred.

Advanced slow-magic angle spinning probe for magnetic resonance imaging and spectroscopy

Growing community of inventors

Kennewick, WA, United States of America

Kevin Minard