Kao Corporation

Kentaro Kumihashi

Tomohiro Shirai

Hiroshi Kusuoku

Mitsuyoshi Sakasai

Hiroshi Hashimoto

Hirohiko Ishida

Daisuke Yamazaki

Takashi Kurahashi

Kazuki Kinoshita

Hirohisa Fujihara

Nanae Mugita

Hiroko Takatoku

The present invention provides a processed plant product having an excellent TRPM8 activating action, a method for producing the same, and a cooling agent and a TRPM8 activator comprising the processed plant product. A method for producing a processed nutmeg product, comprising a step of simultaneously treating nutmeg or an extract thereof with an alcohol or a 25% (v/v) or more alcohol aqueous solution and one or more selected from a protonic acid and an H-type cation exchange resin.

Processed nutmeg product and method for producing same

Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein Rand Reach independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, Rrepresents an alkyl group having 1 to 6 carbon atoms, Rrepresents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond. 

Agent for reduction of sensory irritation

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein Rrepresents a hydrogen atom; Rrepresents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or a hydroxyl group; Rrepresents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and Rrepresents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

Cooling agent and TRPM8 activator

To provide a method for objectively evaluating or screening to identify a substance which is capable of suppressing or regulating olfaction. A method of evaluating or screening to identify an agent for suppressing olfactory sensitivity, including adding a test substance to a substrate having a voltage-dependent cation channel and evaluating or selecting a substance that inhibits an electrical activity caused by the cation channel. A method of evaluating or screening to identify an agent for suppressing olfactory sensitivity, including the following steps (1) to (4): (1) adding a test substance to a substrate having a voltage-dependent cation channel; (2) measuring electrical activity caused by the voltage-dependent cation channel; (3) comparing the electrical activity measured in step (2) with the corresponding electrical activity in a control group; and (4) evaluating or selecting the test substance that inhibits the electrical activity as an agent for suppressing olfactory sensitivity, based on the results obtained in step (3).

Method for screening olfactory sensibility inhibitor

An excellent potential-dependent cation channel inhibitor or an excellent masking agent is provided. Disclosed is a method for inhibiting a potential-dependent cation channel or a method for masking olfaction, both of which include administering an adamantane derivate represented by the following formula (1) or a salt thereof [wherein Rand Rare identical with or different from each other, and each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; and X represents &#x2014;OH, &#x2014;R&#x2014;OH (wherein Rrepresents an alkylene group having 1 to 6 carbon atoms), &#x2014;NH, &#x2014;R&#x2014;NH(wherein Rrepresents an alkylene group having 1 to 6 carbon atoms), &#x2014;COOH, &#x2014;R&#x2014;COOH (wherein Rrepresents an alkylene group having 1 to 6 carbon atoms), &#x2014;CO-R(wherein Rrepresents an alkyl group having 1 to 6 carbon atoms), &#x2014;CO&#x2014;R&#x2014;COO&#x2014;R(wherein Rrepresents an alkylene group having 1 to 6 carbon atoms, and Rrepresents an alkyl group having 1 to 6 carbon atoms), or &#x2014;NHCO&#x2014;R(wherein Rrepresents an alkyl group having 1 to 6 carbon atoms)]. 

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Utsunomiya, Japan

Kentaro Kumihashi