Tanaka Kikinzoku Kogyo K.k.

Tokyo Institute of Technology

Kyoto University

Tokushima University

Kenji Goto

Kunihiro Shima

Yasushi Masahiro

Hiroo Iwata

Hideki Hosoda

Asaka Ueno

Tomonobu Kodama

Akira Umise

Ryusuke Nakai

Yuya Kato

Michimasa Okubo

Tomonari Inamura

Masaki Tahara

Masayuki Saito

Kojiro Shiraishi

Toshiyuki Shigetomi

Kunihiro Tanaka

Hirofumi Nakagawa

Yusuke Doi

Yuri Shinohara

Kenichi Hamada

Eiichi Honda

Shubham Yadav

Tomohiko Morita

Emi Takegawa

Kota Fuchiwaki

Hideki Hosada

The present invention provides a shape-memory alloy including a Au—Cu—Al alloy having 20 at % or more and 40 at % or less Cu and 15 at % or more and 30 at % or less Al, with the balance being Au and inevitable impurities. The shape-memory alloy has a Vickers hardness of 360 Hv or less. The Au—Cu—Al alloy of the present invention is an alloy capable of developing both biocompatibility and a shape-memory effect, and further capable of achieving artifactlessness in a magnetic environment. The Au—Cu—Al alloy can be produced by heat-treating a clad material formed of a combination of a hollow material made of a Au—Cu alloy and a core material made of metallic Al at 500° C. or more and 700° C. or less.

Shape-memory alloy and shape-memory alloy wire

The present invention relates to an alloy for medical use, including Pt, Co, Cr, Ni, and Mo. The alloy includes 10 atom % or more and 30 atom % or less of Pt, 20 atom % or more and 31 atom % or less of Cr, 5 atom % or more and 24 atom % or less of Ni, 4 atom % or more and 8 atom % or less of Mo, the balance Co, and unavoidable impurities, and a ratio of the Ni content (C) to the Pt content (C), C/Cis 1.5 or less. The present invention can be applied to various kinds of devices for medical use, such as catheter, embolic coils, and guide wires, in addition to stents such as flow-diverter stents.

Pt&#x2014;Co based alloy for medical use

The present invention is an embolization coil having an optimum morphological stability. The embolization coil includes a wire material made of an Au&#x2014;Pt alloy. The wire material constituting the embolization coil has such a composition that a Pt concentration is 24 mass % or more and less than 34 mass %, with the balance being Au. The wire material has such a material structure that a Pt-rich phase of an Au&#x2014;Pt alloy having a Pt concentration of 1.2 to 3.8 times a Pt concentration of an &#x3b1; phase is distributed in an &#x3b1; phase matrix. The wire material has a bulk susceptibility of &#x2212;13 ppm or more and &#x2212;5 ppm or less. In a material structure of a transverse cross-section of the wire material, an average value of two or more average crystal particle diameters measured by a linear intercept method is 0.20 &#x3bc;m or more and 0.35 &#x3bc;m or less.

Embolization coil and method for producing embolization coil

The present invention relates to a medical Au&#x2014;Pt&#x2014;Pd alloy including Au, Pt, Pd, and inevitable impurities. The alloy has an alloy composition inside a polygon (A1-A2-A3-A4-A5-A6) surrounded by straight lines connected at point A1 (Au: 37.9 atom %, Pt: 0.1 atom %, and Pd: 62 atom %), point A2 (Au: 79.9 atom %, Pt: 0.1 atom %, and Pd: 20 atom %), point A3 (Au: 79.9 atom %, Pt: 20 atom %, and Pd: 0.1 atom %), point A4 (Au: 69.9 atom %, Pt: 30 atom %, and Pd: 0.1 atom %), point A5 (Au: 49 atom %, Pt: 30 atom %, and Pd: 21 atom %), and point A6 (Au: 39 atom %, Pt: 40 atom %, and Pd: 21 atom %) in a Au&#x2014;Pt&#x2014;Pd ternary state diagram. The metal structure of the alloy is optimized, and the metal structure is close to a single-phase structure, and has little precipitation of a Au-rich phase and a Pt-rich phase different in composition from a mother phase.

Medical Au-Pt-Pd alloy

The present invention provides an alloy for medical use including an Au&#x2014;Pt alloy, in which the Au&#x2014;Pt alloy has a Pt concentration of 24 mass % or more and less than 34 mass % with the balance being Au, and has at least a material structure in which a Pt-rich phase having a Pt concentration higher than that of an &#x3b1;-phase is distributed in an &#x3b1;-phase matrix, the Pt-rich phase has a Pt concentration that is 1.2 to 3.8 times the Pt concentration of the &#x3b1;-phase, and the Pt-rich phase has an area ratio of 1 to 22% in any cross-section. This alloy is an artifact-free alloy material that exhibits excellent compatibility with a magnetic field environment such as an MRI and has magnetic susceptibility of &#xb1;4 ppm with respect to magnetic susceptibility of water.

Alloy for medical use, and method for producing same

The present invention provides an artifactless superelastic alloy including a Au&#x2014;Cu&#x2014;Al alloy, the superelastic alloy containing Cu in an amount of 20 atom % or more and 40 atom % or less, Al in an amount of 15 atom % or more and 25 atom % or less, and Au as a balance, the superelastic alloy having a bulk magnetic susceptibility of &#x2212;24 ppm or more and 6 ppm or less. The Ni-free superelastic alloy of the present invention is capable of exhibiting superelasticity in a normal temperature range, and hardly generated artifacts in a magnetic field environment. The alloy can be produced by setting a casting time in a melting and casting step to a fixed time, and hot-pressing an alloy after casting to make material structures homogeneous.

Artifactless superelastic alloy

The present invention provides a superelastic alloy formed by addition of Fe or Co to an Au&#x2014;Cu&#x2014;Al alloy, including: Cu of 12.5% by mass or more and 16.5% by mass or less; Al of 3.0% by mass or more and 5.5% by mass or less; Fe or Co of 0.01% by mass or more and 2.0% by mass or less; and a balance Au, and a difference between Al content and Cu content (Cu&#x2014;Al) is 12% by mass or less. The superelastic alloy according to the present invention has superelastic property while being Ni-free, excellent X-ray imaging property, processability, and strength property, and is suitable for a medical field.

Superelastic alloy

The present invention provides a superelastic alloy containing Au in an amount of 8.0% by mass or more and 20.0% by mass or less and at least one of Cr and Mo as essential additive elements, Ta as an optional additive element, and Ti and inevitable impurities as a balance, wherein the Cr equivalent calculated on the basis of the following formula for the relationship of the Cr content, the Mo content and the Ta content is within the range of more than 0.5 and less than 8.0. The alloy is a Ni-free superelastic alloy, and has favorable X-ray-imaging property. Accordingly, the alloy can be suitably used in medical fields.Cr equivalent=[Cr content (% by mass)]+([Mo content (% by mass)]/1.7)+([Ta content (% by mass)]/15)&#x2003;&#x2003;[Formula 1]

The present invention is an alloy for medical use including an Au&#x2014;Pt alloy, containing 34 to 36 mass % of Pt with the balance being Au, and having an &#x3b1;-phase single structure in which a ratio of a peak intensity (X) of a Pt (111) plane to a peak intensity (Y) of an Au (111) plane (X/Y) is 0.01 or less in an X-ray diffraction analysis. The alloy can be produced in such a manner that after the Au&#x2014;Pt alloy ingot is molten and cast, cold working and a heat treatment for homogenization are performed at least two times on the molten and cast alloy. The alloy of the present invention is an artifact-free material that exhibits excellent compatibility with a magnetic field environment such as an MRI and has magnetic susceptibility of &#xb1;4 ppm with respect to that of water.

Alloy for medical use and method of producing the same

The present invention is a method for producing dodecacarbonyl triruthenium (DCR) including a process of carbonylating ruthenium chloride with carbon monoxide, in which an amine is added to a reaction system at 0.8 molar equivalent or more with respect to chlorine of the ruthenium chloride and the carbonylation is conducted at a reaction temperature of 50 to 100&#xb0; C. and a reaction pressure of 0.2 to 0.9 MPa. According to the present invention, it is possible to produce dodecacarbonyl triruthenium having less residual impurity metals without applying a reaction condition of a high pressure.

Production method for dodecacarbonyl triruthenium

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Hiratsuka, Japan

Kenji Goto