Meiji Co., Ltd.

Meiji Dairies Corporation

Meiji Dairires Corporation

Keisuke Furuichi

Kakuhei Isawa

Nobuo Yoda

Yoshio Sato

Mizue Saito

Seiya Makino

Shuji Ikegami

Naoki Taketomo

Kenichi Hojo

Tomonori Kamiyama

Tadao Saito

Katsunori Kimura

Yasushi Kawai

Hideaki Uchida

Hiroyuki Itou

Naoki Orii

Hiroshi Kano

Satoru Ozaki

Takayuki Toshimitsu

Yoshiro Sato

Kenichi Hojyo

Provided is a method of producing a culture product of a microorganism, for obtaining a culture product excellent in anti-inflammatory property in which a ratio between the production amounts of IL-10 and IL-12 (ratio of IL-10/IL-12) is large. Specifically, provided is a method of producing a culture product of, including culturingusing a medium containing an unsaturated fatty acid ester until a time point at or before an end of a logarithmic growth phase, to thereby obtain a culture product of. The unsaturated fatty acid ester is an ester formed through a reaction between a monovalent or polyvalent unsaturated fatty acid and a polyhydric alcohol, or a derivative of the ester. A preferred example of the unsaturated fatty acid ester is a monooleic acid ester.

Method for producing culture product of

A process for producing 1,4-dihydroxy-2-naphthoic acid, comprising initiating the culture of 1,4-dihydroxy-2-naphthoic acid producing bacteria belonging to propionic acid bacteria under anaerobic conditions and culturing the bacteria under aeration into a medium when the concentration of a carbon source in the medium is% by mass or less.

Process for producing 1,4-dihydroxy-2-naphthoic acid

screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli compatible with ABO blood groups can be screened by setting 100 RU as a criterion for judging bacterial binding under certain conditions. Using 238strains, the above-mentioned screening methods and tests to judge their compatibility for the use of yogurt production were carried out, to at long last specifically discoverstrains compatible with blood groups A, B, and O.

Method for screening human ABO blood group-binding lactobacilli

A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genusand collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.

Human ABO blood group-binding lactobacilli

A process for producing 1,4-dihydroxy-2-naphtoic acid, comprising initiating the culture of 1,4-dihydroxy-2-naphthoic acid producing bacteria belonging to propionic acid bacteria under anaerobic conditions and culturing the bacteria under aeration into a medium when the concentration of a carbon source in the medium is 3.5% by mass or less.

Process for producing 1, 4-dihydroxy-2-naphthoic acid

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Tokyo, Japan

Keisuke Furuichi