Ecole Polytechnique Federale De Lausanne

Roche Sequencing Solutions, Inc.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Ke Liu

Jiandong Feng

Aleksandra Radenovic

Yann A Astier

Oded Shoseyov

Yuval Nevo

Danny Porath

Dvir Marom Rotem

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

Nanopore forming method and uses thereof

The invention relates to a hybrid structure comprising perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.

Hybrid nanopores and uses thereof for detection of analytes

Molecular sensing system including: a sensing device () comprising at least one support layer (), and an active layer () mounted on said support layer and having at least one nano-pore () configured for translocation of a molecular analyte () therethrough; an electrically conducting liquid () in contact with the active layer in a region around said nano-pore; and a signal processing circuit () comprising an ionic current circuit () configured to generate and measure an ionic current (Ii) in the electrically conducting liquid influenced by the translocation of the molecular analyte through the nano-pore. The molecular sensing device of the invention allows for single-nucleotide discrimination and detection of the specific sequence within ssDNA.

Molecular sensing device

The invention relates to a hybrid structure including perforated solid substrate having at least one nanopore perforating therethrough, and devices and uses thereof.

Growing community of inventors

Chavannes-pres-Renens, Switzerland

Ke Liu