N.v. Nutricia

Other

Nutricia N.v.

Katrien Maria Jozefa Van Laere

Robert Johan Joseph Hageman

Günther Boehm

Eline Marleen Van Der Beek

Martine Sandra Alles

Houkje Bouritius

Maria Elisabeth Hermien De Lange

Peter Antonio Navarro Y Koren

Marcel Minor

Mirian Lansink

Amanda Johanne Kiliaan

Wynette Hermina Agnes Kiers

Johannes Wilhelmus Timmermans

Evan Abrahamse

Renate Maria Louise Zwijsen

Pieter Brandt Bijlsma

Jan Van Der Meulen

Jacques Alphons Groot

Hubertus Josephus Maria Van De Heijning

Elmo Wissing

Chantal Severijnen

Frederik Gerhard Johan Te Hennepe

Arie Gijsbert Nieuwenhuizen

Hubertus Josephus Van De Heijning

Anna Christina Goedhart

The invention relates to a combination of heat-treated nutritional composition having a carbohydrate fraction comprising a) 5-30 wt % of one or more monosaccharides selected from galactose, ribose and mannose; b) carbohydrates capable of providing b1) sustained release glucose and b2) rapidly available glucose; c) optionally fructose; d) glucose-containing disaccharides other than maltose and sucrose; and e) optionally sugar polyols. The invention also pertains to the use of such a heat-treated nutritional composition for controlling glucose levels in blood and/or tissue, especially for preventing and/or treating diabetics, insulin-resistance, obesity, postprandial glucose response, metabolic syndrome, syndrome X, hyperglycemia, hypertriglyceridemia, hyperinsulinemia, dyslipidemia, dysfibrinolysis and/or disorders associated with major surgery or trauma.

Carbohydrate fraction and use thereof for a flat postprandial glucose response

A low-glycemic available carbohydrate composition of the invention contains the following components:

Carbohydrate composition for flat glucose response

Indigestible oligosaccharides having a molecular weight of 450 Da to 3700 Da are used for the improvement of insulin resistance, the prevention of post-prandial glycaemic dip, and/or the decrease of the post-prandial glucose response of a meal, which is consumed within 72 hours after the consumption of the first product. The oligo-saccharides are especially galacto-oligosaccharides, and are advantageously administered a few hours prior to having the meal.

Nutritional products comprising saccharide oligomers

A nutritional composition having beneficial effect in the gastrointestinal tract, especially an anti-adhesion effect on pathogenic micro-organisms and a bifidogenic effect, contains non-digestible oligosaccharides, said oligosaccharides comprising, per daily dosage, 0.3-10 g of oligosaccharides containing at least one terminal arabinose unit. The nutritional composition may furthermore comprise 0.5-10 g of other non-digestible oligosaccharides selected from fructo-oligosaccharides, galacto-oligosaccharides, xylo-oligosaccharides and manno-oligosaccharides. The arabino-oligosaccharides can be obtained conveniently by controlled hydrolysis of arabinose-containing polysaccharides from natural (vegetable) origin.

Nutritional composition with health promoting action containing oligosaccharides

A liquid edible composition with a pH of more than 6, a viscosity below 600 mPas at a shear rate of 100s-1 and 20&#xb0; C., and a viscosity of at least 125% of the aforementioned viscosity at a pH below 5 and a temperature of 37&#xb0; C., the composition comprising at least 0.05 wt. % of pectin having a degree of methoxylation between 2 and 50 and/or of alginate; at least 5 mg calcium per 100 ml; and at least 0.1 wt. % indigestible oligosaccharide having a degree of polymerisation between 2 and 60. Another aspect of the invention relates to a method for the treatment or prevention of overweight or obesity in mammals, the method comprising the enteral administration to a mammal of an effective amount of the aforementioned composition.

Matrix-forming composition containing pectin

The present invention relates to a method for the treatment and/or prevention of overweight in a monogastric mammal. More particularly, the invention is concerned with such a method comprising administering to the mammal a liquid edible composition with a pH of more than 5, a viscosity below 50 mPas at a shear rate of 100sand 20&#xb0; C., and a viscosity of at least 125% of the aforementioned viscosity at a pH 3 and a temperature of 37&#xb0; C.; and with a caloric density between 0 and 500 kcal per liter, the composition comprising: between 0.01 and 5 wt. % of one or more polysaccharides selected from the group consisting of pectin and alginate; and between 0.01 and 3 wt. % calcium

Soft drink replacer

One aspect of the present invention relates to a liquid edible composition with a pH of more than 6, a viscosity below 600 mPas at a shear rate of 100sand 20&#xb0; C., and a viscosity of at least 125% of the aforementioned viscosity at a pH below 5 and a temperature of 37&#xb0; C., the composition comprising at least 0.05 wt. % of pectin having a degree of methoxylation between 2 and 50 and/or of alginate; at least 5 mg calcium per 100 ml; and at least 0.1 wt. % indigestible oligosaccharide having a degree of polymerisation between 2 and 60. Another aspect of the invention relates to a method for the treatment or prevention of overweight or obesity in mammals, said method comprising the enteral administration to a mammal of an effective amount of the aforementioned composition.

The present invention relates to the use of one or more non-digestible polysaccharides selected from the group consisting of dextrans having a molecular weight of 8 kD to 40,000 kD, hydrolysed (gluco)mannans having a molecular weight of 0.5 kD to 1,000 kD and hydrolysed (galacto) mannans having a molecular weigth of 0.5 kD to 1,000 kD for the preparation of a nutritional composition to reduce the uptake of high molecular weight substances, allergens and microorganisms through the intestinal wall, more particularly to reduce transport of high molecular weight substances, allergens and microorganisms through the tight junctions in the intestines, the rise in the viscosity of the nutritional composition caused by the polysaccharides being less than 20 mPa.s. The nutritional compositions can be used to prevent or to treat allergy, allergic reactions, sepsis and inflammatory processes, such as can arise under emotional and physical stress, ischaemia, reperfusion damage during and after operations, after radiation treatment and/or chemotherapy of cancer patients and in the case of inflammatory diseases of the intestine, diarrhoea and allergies.

Nutritional composition which contain non-digestible polysaccharides and use thereof to reduce transport through tight junctions

Procyanidin, optionally combined with hydroxycitric acid, is used in a method for the reduction of appetite in a mammal. Preferably procyanidin is administered to the mammal in a dosage of between 0.5 and 100 mg per kg bodyweight. Also shown is a process for the manufacture of an appetite reducing composition.

Reducing appetite in mammals by administering procyanidin and hydroxycitric acid

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Heteren, Netherlands

Katrien Maria Jozefa Van Laere