Shionogi Company Limited

Jun'ichi Shoji

Kouichi Matsumoto

Naoki Tsuji

Eiji Kondo

Kentaro Tanaka

Tadashi Yoshida

Yoshimi Kawamura

Teruo Hattori

Shigeru Matsutani

Koichi Matsumoto

Hitoshi Arita

Shinzo Matsuura

Mikao Mayama

Yoshiharu Wakisaka

Keizo Inoue

This invention provides a novel compound of the formula: ##STR1## wherein X is L-HyPro or L-Pro, R is --CH.sub.3 or --CH(CH.sub.3).sub.2, and n is an integer from 9 to 12, or its salt, a process for producing the compound which comprises cultivating a microorganism which belongs to the genus Pseudomonas and produces the compound in a medium and recovering the compound from the medium and a biologically pure culture of Pseudomas sp. PB-6250 producing the compound.

Antibiotics plusbacin

A compound of the formula: ##STR1## wherein the wave line means .alpha.-bond or .beta.-bond, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.

Phospholipase A2 inhibitor

A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.1 of the formula: ##STR1## being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and recovering PA-39504-X.sub.1 from the cultured broth.

Antibiotic PA-39504-X.sub.1 and production thereof

A new antibiotic having .beta.-lactamase inhibitory activity, PA-39504-X.sub.3 of the formula: ##STR1## and the pharmaceutically acceptable slats being useful as a drug, a animal drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces argenteolus PA-39504 or Streptomyces tokunonensis PA-31088 in a suitable medium and isolating PA-39504-X.sub.3 from the cultured broth.

Antibiotic PA-39504-X.sub.3 and production thereof

A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.

Antibiotic PA-31088-IV and production thereof

A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium and recovering cephamycin C from the fermentation broth.

Process for preparing cephamycin C

A new antibiotic, 342-14-I, bein useful as a medicament and veterinary drug for inhibiting the growth of gram-positive pathogenic microorganism, and a process for preparing the same, being characterized by cultivating a 342-14-I-producing strain of microorganism belonging to the Genus Bacillus in an aqueous nutrient medium under aerobic conditions.

Growing community of inventors

Hirakata, Japan

Jun'ichi Shoji