University of Utah Research Foundation

Seattle Children's Hospital

Joshua Gustafson

Michael C Jensen

Joseph Cappello

Hamidreza Ghandehari

Robert Andrew Price

Jordan Frandsen

Khaled Greish

Some embodiments provided herein relate to methods and compositions for making genetically modified T cells. In some such embodiments, CD4+ and CD8+ T cells are cultured in a single serum-free volume. In some embodiments, co-cultured CD4+ and CD8+ T cells can be transduced with a lentiviral vector, and a population of transduced T cells can be harvested within a shorter period of time than other conventional methods.

Closed-system manufacturing process for CAR-T cells

A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.

Matrix metalloproteinase cleavable protein polymers for cancer gene therapy

Growing community of inventors

Seattle, WA, United States of America

Joshua Gustafson