Smithkline Instruments, Inc.

Other

Leland Stanford Junior University

Sri International

Joseph I De Graw

M James Barrett

John A Lawson

Howard L Johnson

Ronald G Almquist

Gilda H Loew

This invention relates to novel analogs of proline terminal tripeptides and related compounds and is typified by ##STR1## The compounds are potent inhibitors of angiotensin converting enzyme and as such are useful as antihypertensive agents.

Oxoalkanoic acid derivatives as inhibitors of angiotensin converting

Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives having strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.

N-Sec-alkyl analogs of norcodeine and normorphine and analgesic

Novel folic acid derivatives useful for radioassaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.

Folic acid derivatives and use in radio-assay

Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-.gamma.-glutamyl-tyrosines by iodination with I.sup.125 or I.sup.131.

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Sunnyvale, CA, United States of America

Joseph I De Graw