Ipsen Pharma S.a.s.

Ipsen Manufacturing Ireland Limited

Kinerton Limited

Ipsen Pharma

John Stuart Eynon

Gary Alexander Siwruk

Zheng Xin Dong

Steven A Jackson

Catherine Fiona Dalton

Yeelana Shen

Steven Allen Jackson

A solid phase method for synthesizing a peptide containing three or more amino acid residues utilizing both Boc and Fmoc protected amino acids and a chloromethylated polystyrene resin.

Boc and Fmoc solid phase peptide synthesis

The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a &#x3b2;-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

Methods and intermediates for chemical synthesis of polypeptides and proteins

A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. 

Growth hormone secretagogues

Liquid phase synthesis of peptides and peptide derivatives

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Bellingham, MA, United States of America

John Stuart Eynon