Metabolic Technologies, Inc.

Tsi Group Co., Ltd.

Mti Biotech, Inc.

Metaolic Technologies, LLC

John Rathmacher

Shawn Baier

Naji N Abumrad

John Fuller, Jr

Steve Nissen

Larry Kolb

Naji Abumrad

John Fuller

Martin Purpura

Matthew Legge

Lisa Pitchford

Jay Hoffman

Charles Flynn

Joceylyn Seda

Steven Nissen

Methods and compositions for use in treating, preventing or improving diseases related to the liver in an animal, including but not limited to nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) or nonalcoholic steatohepatitis (NASH), are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

Compositions and methods of use of γ-ketoaldehyde scavengers for treating, preventing or improving nonalcoholic fatty liver disease (NAFLD), NASH, ALD or conditions related to the liver

The present invention provides a composition comprising HMB and at least one probiotic. Methods of administering HMB and at least one probiotic to an animal are also described. HMB and probiotics are administered to attenuate inflammatory cytokine markers and/or maintain muscle integrity.

Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) and probiotics

The present invention provides a composition comprising adenosine or adenosine triphosphate (ATP) acting as an absorption enhancer when combined with a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug. Methods of administering ATP or adenosine to improve the bioavailability of a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug are described.

Compositions containing adenosine triphosphate (ATP) and methods of use

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to modulate autophagy and lipophagy. HMB is also administered to treat, prevent, inhibit, slow or reduce autophagy-mediated conditions or diseases.

Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for modulating autophagy and lipophagy

The present invention provides a composition comprising an acidic formulation containing β-hydroxy-β-methylbutyrate (HMB), preferably in the free acid form, Vitamin D and a stabilizing excipient, wherein the Vitamin D is stabilized against degradation.

Stability of vitamin D in β-hydroxy-β-methylbutyrate (HMB)

The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin D and HMB are administered to increase muscle mass, strength, and functionality. The combination of Vitamin D and HMB together has a synergistic effect, which results in a surprising and unexpected level of improvement in muscle mass, strength and functionality.

Nutritional intervention for improving muscular function and strength

Compositions and methods of use of &#x3b2;-hydroxy-&#x3b2;-methylbutyrate (HMB) for modulating autophagy and lipophagy

The present invention provides a composition comprising an acidic formulation containing &#x3b2;-hydroxy-&#x3b2;-methylbutyrate (HMB), preferably in the free acid form, Vitamin D and a stabilizing excipient, wherein the Vitamin D is stabilized against degradation.

Stability of vitamin D in &#x3b2;-hydroxy-&#x3b2;-methylbutyrate (HMB)

The present invention provides a composition comprising HMB and ATP. Methods of administering HMB and ATP to an animal are also described. HMB and ATP are administered to increase power and strength. The combination of HMB and ATP together has a synergistic effect, which results in a surprising and unexpected level of improvement in power and strength. HMB and ATP are also administered to increase lean body mass and muscle hypertrophy and to prevent typical declines in performance that are characteristic of overreaching.

Composition of HMB and ATP and methods of use

The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.

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Story City, IA, United States of America

John Rathmacher