Nektar Therapeutics

John R Handley

Antoni Kozlowski

Anthony G Schaefer

Brian Bray

Tony L Sander

Ryan Odom

Samuel P McManus

Greg Lavaty

David Swallow

Sachin Tipnis

Seoju Lee

Bhalchandra V Joshi

Patrick Spence

Samuel Mcmanus

Patrick L Spence

Shaoyong Nie

Anthony O Chong

Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate.

Alkoxylation methods

Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.

Salt form of a multi-arm polymer-drug conjugate

Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are related compositions.

Method for preparing polymer maleimides

Methods for preparing conjugates using polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the conjugates.

Method for preparing conjugates using polymer maleimides

Methods for preparing polymeric reagents bearing a maleimide are provided. Also provided are compositions comprising the polymeric reagents, and conjugates prepared by polymeric reagents obtained by the described methods.

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Duluth, MN, United States of America

John R Handley