Novartis Ag

Basilea Pharmaceutica Ag

Joerg Berghausen

Haixia Ren

Pascal Furet

Stefan Stutz

Keiichi Masuya

Philipp Holzer

Edgar Jacoby

Joerg Kallen

Nicole Buschmann

Prasad Koteswara Kapa

Raeann Wu

Carole Pissot Soldermann

Joel Slade

Francois Gessier

Joseph McKenna

François Gessier

Joanna Hergovich Lisztwan

Zhengming Du

Frank Stowasswer

A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively.

Crystalline form of an inhibitor of MDM2/4 and p53 interaction

The present technology provides novel anhydrous and hydrated crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea, amorphous and anhydrous crystalline polymorphs of its monophosphoric acid salt, and the hydrochloride salt, including its dihydrate. The present technology further provides methods for preparing the various forms, compositions containing them, and methods of treatment employing them.

Crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl) -phenylamino]-pyrimidin-4-yl}-1-methyl-urea and salts thereof

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CHor N&#x2014;Rand X, R, R, R, R, Rand n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

Substituted isoquinolinones and quinazolinones

The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant(MRSA) and. 

Cephalosporin in crystalline form

The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant(MRSA) and 

Cephalosporin salts in crystalline form

Growing community of inventors

Lörrach, Germany

Joerg Berghausen