North Carolina State University

Jinqiang Wang

Zhen Gu

Yanqi Ye

A composition comprising a glucose-responsive charge-switchable polymer is described. In the absence of glucose or under normoglycemic conditions, the positively charged polymer can be complexed with negatively charged therapeutic agents, such as insulin. Under hyperglycemic conditions, the positive charge of the polymer is reduced, and the polymer/therapeutic agent complex can disassemble, allowing the therapeutic agent to be released. Pharmaceutical compositions, nanoparticles, and microneedle arrays of the polymer and/or polymer/therapeutic agent complex and methods of treating diabetes are also described.

Charge-switchable polymeric depot for glucose-triggered insulin delivery with ultrafast response

Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with a competitive inhibitor of a glucose transporter, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo.

Glucose transporter inhibitor-modified insulin for glucose-responsive insulin delivery

Disclosed are compositions and methods for microneedle patches comprising diblock copolymer micelles designed for pH cascade and HOtriggered insulin delivery.

Core-shell microneedle patch for HOand pH cascade-triggered insulin delivery

The present disclosure relates to microneedle devices and methods for treating a disease (for example, diabetes) using a degradable cross-linked gel for self-regulated delivery of a therapeutic agent (for example, insulin).

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Raleigh, NC, United States of America

Jinqiang Wang