Centre National De La Recherche Scientifique

Institut National De La Recherche Agronomique (inra)

Jean-Claude Adrien Prome

Jean Louis Denarie

Fabienne Chantal Maillet

Philippe Roche

Patrice Lerouge

William John Broughton

Catherine Faucher

Neil Philip Price

Georges Truchet

Franck Jean Talmont

Biserka Relic

Danielle Jean Prome

Broad host spectrum rhizobiaceae nodulation signals

An essentially pure substance has a structure of a Nod factor or one of its analogues. The Nod factor is characterized by the fact that its biosynthesis is controlled by at least one nodulation gene (nodA,B,C) common to the Rhizobiaceae, in particular to the genera Rhizobium, Bradyrhizobium, Sinorhizobium and Azorhizobium. This substance consists of a lipo-oligosaccharide which is not a derivative of the exopolysaccharides and which has the general formula (I). In formula (I), the Nod factor of which it has the structure is a plant-specific symbiotic signal and is capable of enhancing the capacity of the bacteria of infect the host plant with which it is associated and/or of accelerating the formation of nodules on the host plant with which it is associated and/or of inducing the transcription of symbiotic genes of the leguminoseae. Applications to the treatment of plants and as an active therapeutic agent in humans and animals. G stands for a hexosamine variously substituted, for example by an acetyl group on the nitrogen, a sulphate group, an acetyl group and/or an ether group on oxygen R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, which may be identical or different, stand for H, CH.sub.3 CO--, C.sub.x H.sub.y CO-- where X is a whole number between 0 and 17 and Y is a whole number between 1 and 35, or any other acyl group, for example a carbamyl groups, R.sub.4 stands for a saturated or mono-, di or tri-unsaturated aliphatic chain containing at least 12 carbon atoms and n is a whole number between 1 and 4.

Substance with lipo-oligosaccharide structure capable of acting as

Growing community of inventors

Pechbusque, France

Jean-Claude Adrien Prome