University of Kentucky Research Foundation

University of Texas System

James Zach Hilt

Nicholas Peppas

Mark E Byrne

Thomas D Dziubla

David A Puleo

Paul Fisher

Carolyn T Jordan

Vishwas Talwalkar

Todd Milbrandt

This invention concerns the incorporation of curcumin into the backbone of a hydrolytically degradable crosslinked hydrogel that utilizes poly(beta amino ester) (PBAE) chemistry to provide a tunable protective network with the ability to release at a controlled rate. Upon the introduction of these microparticle systems in to a free radical generating environment, the constituent amount of curcumin present in solution was improved in comparison to a free curcumin state. From these results, a kinetic rate model was developed to estimate oxidative consumption parameters of curcumin and curcumin monoacrylate and quantify theoretical levels of free radicals present depending on the rate of release of curcumin provided. Modeled curcumin conjugated PBAE microparticles improve translation and overall success in delivering a therapeutic agent that matches levels of oxidative stress.

Delivery systems and methods for reactive hydroxyl-containing compounds

The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.

Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles

Biomimetic polymer networks comprising a heteropolymer network having a cavity, the cavity having a selective affinity for a moiety, methods for making biomimetic polymer networks, and methods for using biomimetic polymer networks.

Polymer network compositions and associated methods

Growing community of inventors

Lexington, KY, United States of America

James Zach Hilt