Johns Hopkins University

James R Eshleman

Bert Vogelstein

Kenneth W Kinzler

Nickolas Papadopoulos

Victor E Velculescu

Sian Jones

Ralph Hruban

D Williams Parsons

Scott E Kern

Giovanni Parmigiani

Michael Goggins

Rachel Karchin

Manuel Medina Hidalgo

Alison Klein

Chanjuan Shi

Susan Henrietta Eshleman

Philipp Angenendt

Jimmy Chang-Ho Lin

The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.

Diagnostic method using PALB2

The invention provides methods permitting the detection of small amounts of different nucleic acids in the presence of an excess amount of wild-type nucleic acids. Also provided herein are method so detecting infectious disease minority variants, methods of forensic identification, methods of diagnosing cancer and monitoring disease progress.

Methods for the detection of nucleic acid differences

Growing community of inventors

Lutherville, MD, United States of America

James R Eshleman