The United States of America, As Represented by the Secretary, Department of Health and Human Services

Other

James C Yang

Qiong J Wang

Zhiya Yu

Kenichi Hanada

Nitin Bhandari

David S Gere

Brian J Ray

Herb Schneider

Brian Kline

Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Anti-mutated KRAS T cell receptors

Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Anti-thyroglobulin t cell receptors

Provided herein are modular seating systems for assembling a customizable seating configuration, having: a plurality of frame components, each having: a frame body having legs; a top end having; a groove along each one of the four sides; a corner block at each one of the four corners; a plurality of attachment components, each having: an attachment body; an insert part configured to fit into a groove of the frame components; wherein each attachment component of the plurality of attachment components is configured to associate with any one of the frame components of the plurality of frame components by inserting the insert part of an attachment component into the groove of one of the four sides of the frame body of a frame component.

Systems and methods for modular seating having universal slots

The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding—transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3ζ intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Anti-CD70 chimeric antigen receptors

The couch pocket may comprise a cushion and a pocket. The pocket may be located within the cushion and may therefore be hidden from view when not in use. The pocket may be accessible at the top of the cushion and may be adapted to retain a portable electronic device. As non-limiting examples, the portable electronic device may be a smartphone, a tablet computer, a game controller, or a TV remote control. The pocket may be sized to permit the portable electronic device to stand upright such that the portable electronic device may remain visible while residing in the pocket.

Hidden cushion pocket

Anti-thyroglobulin T cell receptors

A flexible furniture back with 'U' clamp is a steel sofa or chair back having a U-shaped clamp secured to a sofa or chair base providing a back capable of horizontal movement. The furniture back has a plurality of steel cross-member supports. Additionally, the furniture back has padding about the front face and rear face of the back thereby providing cushioning.

Flexible furniture back

The invention provides a chimeric antigen receptor (CAR) having antigenic specificity for CD70, the CAR comprising: an antigen binding-transmembrane domain comprising a CD27 amino acid sequence lacking all or a portion of the CD27 intracellular T cell signaling domain; a 4-1BB intracellular T cell signaling domain; a CD3&#x3b6; intracellular T cell signaling domain; and optionally, a CD28 intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.

Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of thyroglobulin (TG), TG. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the disclosure are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

T cell receptors and related materials and methods of use

A wireless network access point with an integrated sensor to sense and receive input unrelated to control of or data transmitted via the wireless network access point.

Wireless network access point and sensor

A gas lighter which operates by depressing an operating lever to lift a gas pipe thereby opening a gas release valve while a spark is generated by simultaneous rotation of a striker wheel in engagement with a flint has a safety mechanism for ensuring that the valve is closed when the operating lever is released. The safety mechanism includes a spring element which urges the operating lever out of engagement with the gas pipe in the released position.

Growing community of inventors

Bethesda, MD, United States of America

James C Yang