Cj Cheiljedang Corporation

Jae Ick Sim

Jeong Hwan Kim

Hyun Soo Kim

Young Hoon Park

Min Ji Baek

Jong Soo Choi

Chul Ha Kim

Hyoung Seok Kim

Jung Gun Kwon

Jin Nam Lee

Ki-Hoon Oh

Yoon-Suk Oh

Soo Youn Hwang

Hye Jin Choi

Heung-Chae Jung

Jong-Kwon Han

Hyoung Suk Kim

Jae-Gu Pan

Tae Min Ahn

Na Ra Kwon

Kuk-Ki Hong

Tae Sun Kang

Min-Ji Baek

Han-Seung Lee

Eui-Joong Kim

Kyung Oh Choi

Disclosed herein are ammonia-specific 5'-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5&#x2032;-XMP aminase. The resulting 5&#x2032;-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5&#x2032;-XMP into 5&#x2032;-GMP. Thus, the ammonia-specific 5&#x2032;-XMP aminase mutant is stabler within cells compared to the wild type, and can be useful in the industrial conversion of 5&#x2032;-XMP into 5&#x2032;-GMP.

Ammonia-specific 5'-XMP aminase mutant

A microorganism of the genushaving the ability to produce inosine in which the inosine catabolic pathway is blocked and that has a leaky adenine auxotrophic phenotype and further has a leaky guanine auxotrophic phenotype and a method of producing inosine, the method including culturing the microorganism of the genusare disclosed.

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Growing community of inventors

Icheon-si, South Korea

Jae Ick Sim