USA As Represented by Secretary of the Navy

Other

Baker Manufacturing Company, Inc.

Jack C Rife

Milton N Kabler

James S Horwitz

Michael I Bell

Lloyd J Whitman

Neil C Lien

William R Hunter

Johnny P Kirkland

Amand A Lucas

Stephen E Donnelly

Richard T Williams

This invention describes a method of using controlled fluidic forces to improve the performance of a biochemical binding assay where a target molecule is captured by specific molecular recognition onto a substrate surface with an affinity coating, and then labeled with a detectable micrometer-scale particle using a second specific molecular recognition reaction with the target. By using specific ranges of label sizes and laminar flow conditions, controlled fluidic forces can be applied to the label particles in order to selectively remove molecules bound to a surface according to their binding strength, and thereby increase the ratio of specifically bound labels to more weakly attached non-specifically bound labels. This method can be used with a wide variety of label types and associated detection methods, improving the sensitivity and selectivity of a broad range of binding assays.

Fluidic force discrimination

A method for fabricating a transducer suitable for a fluidic drive for a miniature acoustic-fluidic pump or mixer that includes an acoustic transducer attached to an exterior or interior of a fluidic circuit or reservoir. The transducer converts radio frequency electrical energy into an ultrasonic acoustic wave in a fluid that in turn generates directed fluid motion through the effect of acoustic streaming. The method includes depositing a piezo-electric thin-film onto a platinum coated silicon wafer or substrate with capping electrodes, defining each separate transducer; and dicing said piezoelectric tin-film to provide individual transducers.

Method for fabricating a transducer

The fluidic drive for miniature acoustic-fluidic pump and mixer is comprised of an acoustic transducer attached to an exterior or interior of a fluidic circuit or reservoir. The transducer converts radio frequency electrical energy into an ultrasonic acoustic wave in a fluid that in turn generates directed fluid motion through the effect of acoustic streaming. Acoustic streaming results due to the absorption of the acoustic energy in the fluid itself. This absorption results in a radiation pressure and acoustic streaming in the direction of propagation of the acoustic propagation or what is termed &ldquo;quartz wind&rdquo;.

Method for constructing a fluidic driver for use with microfluidic circuits as a pump and mixer

Fluidic drive for miniature acoustic fluidic pumps and mixers

Method and device for producing photons in the ultraviolet-wavelength

A scanning monochromator is disclosed which is capable of operation over a wide bandwidth in an ultra-high vacuum. The monochromator includes a pair of carousel assemblies carrying the optical elements which may be independently positioned translationally along the optical axis of the instrument and also rotationally, which each positioning control operable from outside of the instrument. A carousel on each of the carousel assemblies carries several optical elements and is rotatable to change which optical element is used, also from outside of the instrument.

Wide band scanning monochromator

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Washington, DC, United States of America

Jack C Rife