Institute of Organic Chemistry and Biochemistry Ascr, V.v.i.

Ivan Rosenberg

Gabriel Birkus

Ondrej Pav

Radim Nencka

Ondrej Simak

Tomas Jandusik

The present invention relates to 3'3&#x2032;-cyclic dinucleotides modified with a 3&#x2032;-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.

3'3&#x2032;-cyclic dinucleotides

The present disclosure relates to 2'3&#x2032; cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

2'3&#x2032; cyclic dinucleotides with phosphonate bond activating the sting adaptor protein

The present disclosure relates to 2'3&#x2032;-cyclic dinucleotides modified with a 2&#x2032;- or 3&#x2032;-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.

2'3&#x2032;-cyclic dinucleotides

Provided herein are the 3'3&#x2032; cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

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Prague, Czechia

Ivan Rosenberg