Battelle Memorial Institute

Hoffmann-la Roche Inc.

Intracel Corporation

Iqbal Siddiqi

Jean Brochot

Hans-Rudolf Wuhrmann

Ranald M Sutherland

Christian Roehrich

Ciaron Mangan

Tito Suva

The method makes use of the action of the co-enzyme in the production of H.sub.2 O.sub.2 associated with the reaction of a hydroxylase with a decoupling agent in the presence of air or oxygen, the H.sub.2 O.sub.2 being subsequently determined by quantitative breaking of the C--F bond of a fluorinated compound in the presence of peroxidase, followed by electrometric titration of the resulting ions.

Method of measuring a co-enzyme

A quick and simple immunoassay technique applicable to the determination of large molecules like proteins, polynucleotides and others involves labelling competitive immunospecies with an enzyme as signal generator. This enzyme can be converted to the corresponding apo-enzyme form and its regeneration, upon addition of a suitable co-factor, is inhibited by complexation when the labelled specie is reacted with its immunopartner. The degree of complexation is therefore ascertained by measuring the extent of regenerated activity.

System of reactants involving an apo-enzyme useful in immunological

There is disclosed a process for producing a laminar electrode. The method comprises successive superposition of an insulating support, a conductive layer, a stable-potential internal reference element and an ion-selective diaphragm, all of which are protected by a mask which is impermeable to aqueous solutions. A completely tight seal between the mask and the ion-selective diaphragm is formed by casting the diaphragm in the form of a solution containing a binder which dissolves with and intimately mixes with the mask material.

Method of manufacturing ion-selective electrodes for analyzing selected

The electrode comprises an internal reference half-cell at stable potential comprising a conductive sheet, e.g. of metal of carbon, covered by a redox system. The redox system comprises a thin dehydrated layer of Prussian blue deposited by contact between the sheet and a mixture of alkaline ferrocyanide and a ferric salt.

Selectively ion-permeable dry electrodes for analyzing selected ions in

An analyte sample of blood serum is reacted with a protease in excess over that quantity required to provide a 1:1 protease:inhibitor complex. The excedent protease is then back-titrated using the reaction with diphenylcarbamyl fluoride and measuring electrometrically the liberated fluoride.

Analytical process and means for measuring protease inhibitor capacity

Test strip for the dip and read colorimetric determination of substances dissolved in liquids. Such strips are composed of an inert supporting base covered with a layer of polymer beads in which the reagents are incorporated. The color reaction takes place within the beads themselves which improves sensitivity and reproducibility of the testing.

Test strips for analyzing dissolved substances

Analytical process and means for measuring the amount of hydrogen

A device for colorimetric analysis of samples comprises a plurality of groups of receptacles, means for bringing these groups successively to a testing station, and means for automatically performing a cycle of analysis on the receptacles of the group at that station. The analysis means includes a light source, a photodetector aligned therewith, and a plurality of filters. The receptacles of each group and respective filters are moved successively into alignment with the source and detector so that the contents of each receptacle are analyzed with the aid of the correct corresponding filter.

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Geneva, Switzerland

Iqbal Siddiqi