The Johns Hopkins University

Merck + Co., Inc.

Hugh D Burns

Alfred V Kramer

Kwamena E Baidoo

Susan Z Lever

Wai-Si Eng

Robert Francis Dannals

Raymond E Gibson

Leon A Epps

Susan E Zemyan

The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.

Radiolabeled farnesyl-protein transferase inhibitors

A bifunctional ligand to compositions produced by reaction of the ligand with compounds containing an amino, thiolate or alcholate group, especially proteins, to chelates produced by complexing ligands with metal such as technetium and rhenium and to diagnostic and therapeutic uses of the complexes.

Thiolactone bifunctional chelating agents for diagnostic and therapeutic

A bifunctional ligand to compositions produced by reaction of those ligand with compounds containing an amino, thiolate or alcholate group, especially proteins, to chelates produced by complexing ligand with metals such as technetium and rhenium and to diagnostic and therapeutic uses of said complexes.

The present invention relates to coordination compounds of technetium-99m and chelating agents (ligands) for synthesizing them. The technetium compounds are useful as diagnostic brain imaging radiopharmaceuticals.

Growing community of inventors

Harleysville, PA, United States of America

Hugh D Burns