University of Michigan

University of Houston System

Hua Zhang

Xiaolian Gao

Eric M Leproust

Xiaochuan Zhou

Jean Philippe Pellois

Qin Xiang

Peilin Yu

Peillin Yu

Robert J Schwartz

James M Briggs

Scott R Gilbertson

Chris Mi

Steven Bark

Robert Fox

Reza Abbasgholizadeh

Fei Lu

John W Craft

Kevin MacKenzie

The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory polypeptide blocks ROCK1 activity in the presence of 1 mM ATP. The binding epitope on ROCK1 was mapped using chemical cross-linking to the Activation Loop, a novel locus identifying a new class of inhibitory drugs. The peptides described will be useful against a number of important diseases such as heart disease, pulmonary hypertension, arterial hypertension, glaucoma management, insulin resistance, kidney disease, hemolytic anemia, stroke, ischemia reperfusion injury, or acute myeloid leukemia.

Rho associated kinase (ROCK) inhibitors and their use in treating disease

A double-sided LCLC-compensated network is proposed for a capacitive power transfer (CPT) system. In one design, four metal plates are used to form two power transmitting and receiving capacitors and the LCLC network is used to compensate the capacitors. In the second design, two extra metal plates are used to couple with the previous four plates at the transmitting and receiving side, respectively, which forms the capacitor-integrated structure. The circuit parameter values are tuned to achieve zero voltage switching (ZVS) of the input side switches. There is also a CLLC topology proposed, which is a similar variation of LCLC circuit. A 3.3 kW input power capacitive power transfer prototype is designed and built. The experiment results show that the proposed CPT system can transfer 3.1 kW output power through an air gap distance of 70 mm with a dc-to-dc efficiency of 92.1%.

Double-sided LCLC-compensated topology for capacitive power transfer

A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.

Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports

Growing community of inventors

Houston, TX, United States of America

Hua Zhang