Venus Medtech (hangzhou) Inc.

Sichuan University

Transcatheter Technologies Gmbh

Venus Medtech, Inc.

Hou-Sen Lim

Wolfgang Goetz

Wolfgang Gotz

Li Yang

Dajun Kuang

Yunbing Wang

Jincheng Yu

Wolfgang Götz

Gaocan Li

Yang Lei

Yu Zhang

Zhifei Zhang

Zhenjun Zi

Jianan Wang

Frank Min Zeng

A method for preparing a pre-loadable biological heart valve capable of rapid rehydration includes performing a cross-linking treatment, wherein a biological valve is cross-linked by soaking in an aqueous glutaraldehyde solution; performing a hydrophilic treatment, wherein the biological valve is soaked in a solution containing a hydrophilic molecule and a condensing agent, to allow the hydrophilic molecule to be immobilized on the biological valve by chemical grafting; and performing a drying treatment, wherein the biological valve after the hydrophilic treatment and the cross-linking treatment is dried to obtain the pre-loadable biological heart valve capable of rapid rehydration.

Pre-loadable biological heart valve capable of rapid rehydration and preparation method thereof

A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.

Pre-loadable dried biological heart valve and preparation method thereof

The present invention discloses a core assembly, a sheath assembly, a sheath, a sheath processing method and an interventional instrument delivery system and method. A core assembly for delivering an interventional instrument according to the present invention comprises a core tube, a locking member fixed at a distal end of the core tube for connecting the interventional instrument, and a bendable adjustable tube mounted around an outer periphery of the core tube, wherein the distal ends of the bendable adjustable tube and the core tube are fixedly connected to each other, and the proximal ends can slide relative to each other.

Sheath for delivering interventional instrument and sheath assembly

The present invention relates to a device () intended to be attached to or interconnected with a medical implant (), and intended to be attached to or interconnected with a catheter (), the catheter () being intended for implanting the implant (). The invention further relates to a catheter () suited for receiving at least one such device () and to a method.

Implant delivery device adapted to be attached to or interconnected with a catheter, catheter and method

The present invention relates to an apparatus () for use during implanting at least one medical implant () at an implantation site within a patient's body, wherein the apparatus () comprises an aligning device () for aligning the apparatus () at the implantation site, wherein the aligning device () is capable of being transferred from a non-aligning position into an aligning position. It further relates to a set and a method.

Apparatus comprising an aligning device, set and method

The present invention relates to a handle assembly () for an implant delivery device for folding or unfolding at least one medical implant by means of at least one tension thread, wherein the handle assembly () comprises a drum () for winding the tension thread thereon by rotating the drum (); a knob () to be rotated by a user of the handle assembly () in order to fold or unfold the medical implant, the knob () being interconnected with the drum () such that the drum () is rotated when the knob () is rotated; and a displacement limiter for limiting the length or displacement by which the tension thread () may be at least one of wound onto or unwound from the drum () by rotating the knob ().

Handle assembly for implant delivery apparatus comprising a force limiter, a displacement limiter and/or a brake frame assembly

The present invention relates to a handle assembly () for an implant delivery device for folding or unfolding at least one medical implant by means of at least one tension thread, wherein the handle assembly () comprises a drum () for winding the tension thread thereon by rotating the drum (); a knob () to be rotated by a user of the handle assembly () in order to fold or unfold the medical implant by tightening or winding the tension thread or by releasing or unwinding the tension thread, the knob () being arranged or interconnected with the drum () such that the drum () may be rotated when the knob () is rotated; and a brake frame assembly () comprising at least one brake element and at least one spring () arranged to act on the brake element such that the brake elements contact one surface of the rear knob ().

A method for crimping a medical implant includes at least one foldable and/or unfoldable structure on or around or over a portion or outer surface of a catheter or of a catheter tip. No pressure beyond a predetermined pressure is exerted on the structure during and/or after crimping of the implant.

Expandable medical implant

A collapsible-expandable tubular stent () constructed of shape-memory material which is implantable into a human heart, which comprises proximal and distal rings () and at least two spaced apart posts () that extend axially between said rings (), said distal ring () comprising a plurality of distal arms () which are connected to the distal ring () at only one end and which have a free opposite end; said proximal ring () comprising a plurality of, which are connected at only one end to the proximal ring () and which have a free opposite end, which proximal arms () are constructed to swing radially outward at their free ends.

Minimally invasive mitral valve replacement with brim

A device is intended to be attached to or interconnected with a medical implant, and intended to be attached to or interconnected with a catheter. The catheter is intended for implanting the implant.

An implant, intended to be detachably fixed or crimped on a portion or an outer surface of a catheter for being delivered to an implantation site, includes a longitudinal axis, or an inner space or inner volume longitudinally extending within the implant, and a radial direction perpendicular to the longitudinal axis, space or volume. The implant includes a first structural element having a first portion, a second structural element having a second portion, and one or more interconnecting elements arranged between the first and the second structural elements. In the implant, the first portion and/or the second portion is/are located less radially as regards the longitudinal axis, inner space, or volume than a third portion of the one or more interconnecting elements.

Medical implant maintaining gaps upon crimping, method and delivery device

The present invention relates to an apparatus () for folding or unfolding at least one medical implant () by using at least one tension thread ('), wherein the apparatus () includes a shaft () including a reception area () for receiving the implant (), and a tensioning device for altering a shape of the foldable and/or unfoldable implant () by the tension thread (&#x2032;).

Apparatus for folding or unfolding a medical implant, and implant

The present invention relates to a handle assembly () for an implant delivery device for folding or unfolding at least one medical implant by means of at least one tension thread, wherein the handle assembly () comprises a drum () for winding the tension thread thereon by rotating the drum (); a knob () to be rotated by a user of the handle assembly () in order to fold or unfold the medical implant, the knob () being interconnected with the drum () such that the drum () is rotated when the knob () is rotated; and a force limiter for limiting the maximum force or tension that may be applied or is applicable to the tension thread () or to the drum () by rotating the knob ().

The present invention relates to set comprising an apparatus () for folding or unfolding at least one medical implant () by means of at least one tension thread ('), wherein the apparatus () comprises a shaft () and a tensioning device for altering a form or shape of the foldable and/or unfoldable implant () by means of the tension thread (&#x2032;). In at least one shaft section thereof, the shaft () comprises a plurality of individual shaft fibers ().

Set comprising an apparatus and a medical implant

An apparatus for folding or unfolding at least one medical implant by way of at least one tension thread includes a shaft and a tensioning device for altering a form or shape of the foldable and/or unfoldable implant by way of the tension thread ('). In at least one shaft section thereof, the shaft includes a plurality of individual shaft fibers.

Growing community of inventors

Singapore, Singapore

Hou-Sen Lim