Basf Aktiengesellschaft

Horst Ralf Staudenmaier

Bernhard Hauer

Wolfgang Ladner

Uwe Pressler

Joachim Meyer

Ursula Mueller

Friedhelm Balkenhohl

Ursula Schnell

Hardo Siegel

The present invention relates to a novel process for the preparation, by fermentation, of compounds of the formula I ##STR1## where R.sup.1 is hydrogen, fluorine, chlorine or bromine.

Fermentative preparation of 2,5-dihydroxyphenylacetic acid with Beauveria

A process for hydroxylating compounds of the formula ##STR1## where n, A and R.sup.1 to R.sup.4 have the meanings stated in the description, with the aid of microorganisms of the genus Beauveria.

Process for the hydroxylation of aromatic acids using strains of the

Biotechnological perparation of alcohols, aldehydes and carboxylic acids

2-hydroxyphenylacetic acid is prepared from phenylacetic acid by fermentation with suitable microorganisms.

Preparation of 2-hydroxyphenylacetic acid by fermentation

A process for preparing enantiomerically pure lactams of the formula I ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, H, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.2 -C.sub.4 -alkenyl, unsubstituted or substituted aryl, (CH.sub.2).sub.n --COOH with n=0, 1, 2, 3, and X is 1, 2, 3, 4, 5, from a racemate of the formula I by. allowing a biocatalyst which selectively converts one enantiomer from I to act on the racemic mixture of I, and isolating the unconverted enantiomer from the resulting mixture of products.

Preparation of enantiomerically pure lactams

The invention relates to a novel process for preparing 3-hydroxyphenylacetic acid by cultivating a fungus of the genus Rhizoctonia, Ceratobasidium and Pellicularia in the presence of a phenyl compound of the formula I ##STR1## where X is COOR, CH.sub.2 OH, CH.sub.2 NH.sub.2 or ##STR2## R is methyl, ethyl, hydrogen, sodium, potassium or ammonium.

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Limburgerhof, Germany

Horst Ralf Staudenmaier