Delsys Pharmaceutical Corporation

Sarnoff Corporation

David Sarnoff Research Center, Inc.

Stevens Institute of Technology

Delsys Pharmaceutical Company

Hoi Cheong Sun

Bawa Singh

Nitin Vithalbhai Desai

Timothy Allen Pletcher

Howard Christopher Rivenburg

Dominic Stephen Rosati

Eugene Samuel Poliniak

William Ronald Roach

David A Keller

Joseph Thomas McGinn

Peter David Southgate

Pabitra Datta

David Norman Ludington

Bogdan Brycki

Frank B Lang

Peter John Zanzucchi

Aaron W Levine

James Regis Matey

Suggy S Chrai

Peter James Coyle

William Chiang

Nalin Kumar

Lawrence Harrison Hammer

Gary Santonastaso

Edward A Whittaker

Bryan Lloyd Bentz

Christina Marie Knoedler

Eugene Samuel Puliniak

Zyi Gerald Loewy

William Yat Chung Chiang

Dominic S Rosati

Nitin Vithabhi Desai

An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels. Other embodiments are for impact deflection of a dosage carrying substrate in a cartridge or cassette against an anvil to release the dosages.

Medicament dry powder inhaler dispensing device

Provided is an electrostatic sensing chuck for attracting particles to a portion of a particle contact surface near a deposition electrode, the electrostatic sensing chuck comprising a pixel comprising: a deposition electrode (DE) for selectively establishing an attraction field (E ) at the particle contact surface; a shield electrode (SE) oppositely biased with respect to the deposition electrode; a charge sensing circuit to measure charge accumulated on each of the deposition electrode and the shield electrode, wherein the charge sensing circuit subtracts a second charge it senses at the shield electrode from a first charge it senses at the deposition electrode, thereby determining accumulated charge at the deposition electrode balanced by accumulated charge at the shield electrode.

Electrostatic sensing chuck using area matched electrodes

Provided is, among other things, and together with associated methods, a powder feed comprising: a venturi comprising an external gas inlet, a gas outlet through which gas flows at a rate amplified over a gas flow rate into the external gas inlet, and an internal gas inlet; and a cyclone with an intake port connected to the venturi gas outlet, a recycle outlet port, and a product port, wherein a gas flow rate F into the venturi external gas inlet results in an enhanced flow rate into the cyclone intake port.

Device for the dispersal and charging of fluidized powder

AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck would undergo rapid RC decay and cause the bead transporter chuck to stop working. Methods for selecting AC waveforms are given, including those that maximize the time average of the bead attraction potential at the bead collection zone of the bead contact surface.

AC waveforms biasing for bead manipulating chucks

Provided is a method of fabricating a substrate having on a surface thereof two or more spatially-resolved regions, each with a defined amount or concentration of one of one or more chemical components, the method comprising: associating a chemical component with particles of 1 &mgr;m to 500 &mgr;m diameter; electrostatically depositing the particles on the appropriate regions; and if a said spatially-resolved region is to receive a second chemical component, repeating steps (a) and (b) for that chemical component and the appropriate regions.

Method for controlled electrostatic adherent deposition of particles on a substrate

Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.

Bead or particle manipulating chucks

Acoustic bead charger/dispenser employs a bead dispersion plate (BDP) to align beads with, for example, bead collection zones of a bead transporter chuck, then propel or launch them toward the bead collection zones, using acoustic energy provided by a speaker. The bead dispersion plate can be configured so that the acoustic energy from the speaker may be directed so as to impart to the bead translational kinetic energy primarily in a direction toward the bead collection zone of the bead transporter chuck. The bead dispersion plate can comprise a conductive surface that can be used to accelerate the beads toward the bead transporter chuck. Using sufficient acoustic energy applied by the speaker, sufficient translational kinetic energy can be imparted to beads to remove them from the conductive surface when they are under the influence of an electrostatic image force. The bead dispersion plate can optionally comprise a tribo-charging mesh (MESH) for inductive charge transfer tribo-charging during application of acoustic energy. The bead dispersion plate can comprise a distribution system, including a bead reservoir and metering pump to controllably feed and retrieve the beads from the bead dispersion zones of the bead dispersion plate. Methods are given for using the acoustic bead charger/dispenser to align beads with a bead collection zone of a bead transporter chuck, and to propel the beads toward the bead collection zone.

Focused acoustic bead charger/dispenser for bead manipulating chucks

Bead transporter chucks for selective pick up and discharging of polymer beads for chemical synthesis or analysis, whereby repulsive field conductors are arranged around bead electrodes used for selectively attracting and retaining beads. Problems of bead control are addressed by adding repulsive fields to help guide and direct beads to desired or designated bead collection zones. The repulsive electrodes create non-uniform electric fields that control, focus, and deflect charged beads in the vicinity of the bead collection zone, helping prevent multiple bead retention at intended bead collection zones. For better bead control, and allowing manipulation of beads with higher charge/mass ratios, dielectric material may be positioned around the bead electrode and between the bead electrode and the repulsive field conductor. Multiple bead electrodes may be provided to form two or more bead collection zones, and these may selectively addressed and controlled (e.g, x-y addressing) for individual and selective control of the bead collection zones. Methods and applied voltages are given for using the bead transporter chuck to transport and dispense beads.

Bead transporter chucks using repulsive field guidance and method

Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising:

Dry powder deposition apparatus

Bead manipulating chucks for selective pick up and discharge of polymer beads for chemical synthesis or analysis, whereby bead collection zones are recessed from bead contact surfaces. The strong dependence of the electrostatic image force on bead overall diameters provides a mechanism that sharply selects bead sizes that are successfully attracted and retained by the bead manipulating chuck. In this way, the bead manipulating chuck acts as an electrical analog to a low pass filter, only attracting and retaining beads of an overall diameter lower than a selected value.

Bead manipulating chucks with bead size selector

The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides comprising a sensing electrode, optionally for use with an electrostatic chuck, for sensing the number of particles attracted to the objects on the chuck or other substrate, thereby providing for deposition of an accurate amount of particles.

Electrostatic chucks and a particle deposition apparatus therefor

The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrate In another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.

Inhaler apparatus with an electronic means for enhanced release of dry

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Dayton, NJ, United States of America

Hoi Cheong Sun