Fujisawa Pharmaceutical Company, Ltd.

Hisami Yamaguchi

Satoshi Ueda

Takehisa Hata

Yoshio Ueda

Masateru Kodani

Hisatomi Fukuoka

This invention provides &bgr;-lactam antibiotic-containing tablets capable of being orally taken either as such owing to their being small-sized, hence still easily swallowable, or, in the case of administration to the aged encountering some difficulty in swallowing, in the form of dispersions resulting from easy self-disintegration upon being dropped into water in a glass as well as a method of producing the same. The tablets of this invention comprise, on the per-tablet basis, 60-85% by weight of a &bgr;-lactam antibiotic, 1-10% by weight of low-substituted hydroxypropylcellulose and/or crosslinked polyvinylpyrrolidone as a disintegrator, and 0.5-2% by weight of a binder. Granules to be compressed for tableting are prepared using water or an aqueous solution of ethanol or the like.

&bgr;-lactam antibiotic-containing tablet and production thereof

The invention relates to a Time-Controlled Explosion System in which drug release is caused by explosion of a membrane after a definite time period, said System comprising a preparation in the form of a bead or granule, said preparation comprising a core, a drug, swelling agent and an outer membrane of water-insoluble coating material.

Time-controlled explosion systems and processes for preparing the same

A stopper for a vial has a top portion and legs extending therefrom. The free or distal end of the legs have cut outs on each of the circumferential sides. The cut outs can be either straight or curved and are of such a size that the stopper can be securely held when partially fitted in a vial. The cut outs prevent the stoppers from becoming entangled during pre-treatment.

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Nishinomiya, Japan

Hisami Yamaguchi