The University of Texas System

Sangamo Therapeutics, Inc.

Hiroki Torikai

Simon Olivares

Feng Wang-Johanning

Lenka Hurton

Laurence J Neil Cooper

Janani Krishnamurthy

Ling Zhang

Helen Huls

Philip D Gregory

Laurence J N Cooper

Laurence Jn Cooper

Laurence JN Cooper

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T-cells are producing using electroporation in conjunction with a transposon-based integration system to produce a population of CAR-expressing cells that require minimal ex vivo expansion or that can be directly administered to patients for disease (e.g., cancer) treatment.

Human application of engineered chimeric antigen receptor (CAR) T-cells

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for 'off-the-shelf' treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example.

Car+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for 'off-the-shelf treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example.

CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA

Growing community of inventors

Houston, TX, United States of America

Hiroki Torikai