Gist-brocades N.v.

Van Veen, Gerardus J.

Verweij, Jan

Kalter, Jan

Henniger, Peter W.

Hirs, Henri G.j.

Grootveld, Herman H.

Herman H Grootveld

Everardus J Leenderts

Jan Verweij

Hendrik A Witkamp

Jan J DeKoning

Henri G Hirs

Peter W Henniger

Johannes K Van Der Drift

Herwarth Heitman

Jan Kalter

Jan Verwej

Gerardus J Van Veen

Henri Gj Hirs

A cephalosporin compound substituted in the 7-position with a (cyclo)alkylideneammonio group of formula (II) ##STR1## wherein X' is an anion from an acid HX, R.sub.1 and R.sub.2 are individually a C.sub.1 -C.sub.16 alkyl group, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkylidene ring with up to 8 carbon atoms and a process for the preparation which compounds are useful intermediates.

Cephem derivatives

Process for the preparation of 7.beta.-amino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives, new intermediates comprising 7.beta.-(cyclo)alkylideneammonio-3-halomethyl-3-cephem-4-carbox ylic acid derivatives and 7.beta.-amino/ammonio-3-bromomethyl-3-cephem-4-carboxylic acid derivatives and the processes for the preparation of these intermediates.

Cephalosporin derivatives

Process for the preparation of cephem compounds

A process for the preparation of 7.beta.-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70.degree. C. to 0.degree. C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.

Cephalosporin deoxygenation process

The solvate of sodium amoxicillin and N-methyl-2-pyrrolidone and its preparation which is a stable antibiotic from which injectable solutions may be prepared.

Sodium amoxicillin solvate

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Benthuizen, Netherlands

Herman H Grootveld