Boehringer Mannheim Gmbh

Henry M Grage, Jr

Wolfgang-Reinhold Knappe

Dieter Berger

Bernward Sojka

Manfred Bleisteiner

Waring Charles Lynch

Mark T Skarstedt

Michael W Alderink

Stanley G Brown, Jr

Robert Lorenz

Elon T Van Buren

A ribbon-like flat web having a plurality of side by side depressions is fed through a horizontal slot having a downward facing surface having an aperture communicating with a reservoir of reagent containing solution. The web is urged against the downward facing surface to provide sealing as the solution is fed into the upward facing depressions. The aperture communicating with the reservoir is profiled as a parallelogram having a leading edge which is oblique to the direction of movement. After emerging from the dispensing apparatus the exposed solution is dried in hot air, followed by spray application of a second solution, further drying in hot air, and application of a backing to form capillary chambers. The method is especially useful for manufacturing coagulation assays having magnetic particles and thromboplastin.

Method and apparatus for manufacturing a coagulation assay device in a

On a carrier layer there are arranged several test layers which are at least partly in fluid contact with one another, enabling liquid exchange. On the carrier layer are arranged an application zone, a detection zone for the production of a detectable signal characteristic of the analytical determination, which contains at least one said test layer which is a reaction layer, and an absorption zone with a test layer which is an absorptive layer of an absorbent material, wherein the reaction layer and absorption zone are positioned next to each other. Between the application and the absorption zone is a capillary-active transport path on the carrier layer which connects the application zone and the absorption zone. The reaction layer is arranged parallel to the transport path between the application zone and the absorption zone in such a manner that it is in liquid contact with a liquid transported in the transport path. The absorption zone therefore absorbs excess liquid and permits dosing the reaction layer with a reproducible amount of sample.

Test carrier and method for the analytical determination of components

An apparatus useful in analyzing samples, such as body fluids, is presented. The device is especially useful in analyzing whole blood because its configuration, with a differential vertical dimension permits rapid flow and uniform draw through the device, with contact of the relevant portion of the sample to a reagent means. Also disclosed is a method for analyzing a sample using the device.

Wedge shaped test strip system useful in analyzing test samples, such as

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Carmel, IN, United States of America

Henry M Grage, Jr