The Wistar Institute

The Children's Hospital of Philadelphia

Other

Pfizer Corporation

H Fred Clark

Stanley A Plotkin

Paul A Offit

Tully J Speaker

Manuel Campos

Patrick J Frenchick

Charlotte A Moser

The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavirus. Another reassortant contains the gene encoding the v.p.4 neutralization antigen of a human rotavirus. The remaining genes are provided solely from the bovine rotavirus WC3 strain, or from both the human and bovine strains.

Rotavirus reassortant vaccine

A microencapsulated subunit component from bovine herpes virus-1 (BHV-1) is disclosed. Vaccines, kits, and methods for using the same to vaccinate a member of a bovine species are also disclosed.

Aqueous solvent based encapsulation of a bovine herpes virus type-1 subunit vaccine

The present invention refers generally to a novel human cytopathic rotavirus of serotype 3 (HCR3A) and to its use as a vehicle for the expression of human rotavirus genes. The invention also relates to novel rotavirus reassortants, vaccines employing the novel rotavirus and its reassortants and methods for their preparation and administration.

Human rotavirus HCR3A and method of growing said rotavirus

A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in FIG. 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.

Growing community of inventors

Philadelphia, PA, United States of America

H Fred Clark