East China University of Science and Technology

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

Guoqiang Lin

Yan Mei Zhang

Qian Zhao

Jianhe Xu

Feng Liu

Jiang Pan

Huilei Yu

Amonooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene and a recombinant transformant, a method of preparing the monooxygenase by the recombinant expression transformant, and a method of preparing an optically pure chiral sulfoxide by the monooxygenase, in particular to a method of preparing prazole drugs by means of catalyzing the asymmetric oxidation of thioether, a prazole precursor. As compared with other methods of preparing an optically pure sulfoxide, the product produced by the monooxygenase of the present invention as a catalyst has high optical purity, avoids the generation of the byproduct sulfone, and has advantages of mild reaction conditions, simple and convenient operations, easy amplification, etc.

Bradyrhizobium monooxygenase and use thereof for preparation of chiral sulfoxide

Growing community of inventors

Nanjing, China

Guoqiang Lin